new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50213653'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50213653
PNG
((S)-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)...)
Show SMILES C[C@H](CNCCc1ccncc1)c1c2CN(CCc2[nH]c1-c1cc(C)cc(C)c1)C(=O)C1C(C)(C)C1(C)C
Show InChI InChI=1S/C33H44N4O/c1-21-16-22(2)18-25(17-21)29-28(23(3)19-35-14-10-24-8-12-34-13-9-24)26-20-37(15-11-27(26)36-29)31(38)30-32(4,5)33(30,6)7/h8-9,12-13,16-18,23,30,35-36H,10-11,14-15,19-20H2,1-7H3/t23-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
1.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Displacement of [125I]-Tyr5, DLeu6, NMeLeu7, Pro-N-Et-GnRH from cloned rat GnRHR


Bioorg Med Chem Lett 17: 3845-50 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.009
BindingDB Entry DOI: 10.7270/Q2JD4WHQ
More data for this
Ligand-Target Pair
Gonadotropin-releasing hormone receptor


(Rattus norvegicus)
BDBM50213653
PNG
((S)-(2-(3,5-dimethylphenyl)-3-(1-(2-(pyridin-4-yl)...)
Show SMILES C[C@H](CNCCc1ccncc1)c1c2CN(CCc2[nH]c1-c1cc(C)cc(C)c1)C(=O)C1C(C)(C)C1(C)C
Show InChI InChI=1S/C33H44N4O/c1-21-16-22(2)18-25(17-21)29-28(23(3)19-35-14-10-24-8-12-34-13-9-24)26-20-37(15-11-27(26)36-29)31(38)30-32(4,5)33(30,6)7/h8-9,12-13,16-18,23,30,35-36H,10-11,14-15,19-20H2,1-7H3/t23-/m1/s1
KEGG

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 96n/an/an/an/an/an/a



Neurocrine Biosciences, Inc.

Curated by ChEMBL


Assay Description
Inhibition of GnRHR in rat pituitary cells assessed as inhibition of GnRH-stimulated LH release


Bioorg Med Chem Lett 17: 3845-50 (2007)


Article DOI: 10.1016/j.bmcl.2007.05.009
BindingDB Entry DOI: 10.7270/Q2JD4WHQ
More data for this
Ligand-Target Pair