BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'Gonadotropin-releasing hormone receptor' and Ligand = 'BDBM50258205'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50258205 (2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	5.80	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]D-Trp6-GnRH from human recombinant GNRH receptor by scintillation counting				Bioorg Med Chem Lett 20: 2512-5 (2010) Article DOI: 10.1016/j.bmcl.2010.02.099 BindingDB Entry DOI: 10.7270/Q2W0962G
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50258205 (2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)-GnRH from human GnRH receptor				Bioorg Med Chem Lett 19: 1986-90 (2009) Article DOI: 10.1016/j.bmcl.2009.02.043 BindingDB Entry DOI: 10.7270/Q28S4PS4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50258205 (2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GnRH receptor expressed in HEK293 cells assessed as reduction in (D-Trp6)-GnRH-stimulated IP production by w...				Bioorg Med Chem Lett 19: 1986-90 (2009) Article DOI: 10.1016/j.bmcl.2009.02.043 BindingDB Entry DOI: 10.7270/Q28S4PS4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50258205 (2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...) Show SMILES Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	15	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at human recombinant GNRH receptor assessed as inhibition of D-Trp6-GNRH-induced IP accumulation after 1 hr by rapid filtration a...				Bioorg Med Chem Lett 20: 2512-5 (2010) Article DOI: 10.1016/j.bmcl.2010.02.099 BindingDB Entry DOI: 10.7270/Q2W0962G
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50258205 (2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]D-Trp6-GnRH from rat recombinant GNRH receptor by scintillation counting				Bioorg Med Chem Lett 20: 2512-5 (2010) Article DOI: 10.1016/j.bmcl.2010.02.099 BindingDB Entry DOI: 10.7270/Q2W0962G
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50258205 (2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	24	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Displacement of [125I]-(D-Trp6)-GnRH from rat GnRH receptor				Bioorg Med Chem Lett 19: 1986-90 (2009) Article DOI: 10.1016/j.bmcl.2009.02.043 BindingDB Entry DOI: 10.7270/Q28S4PS4
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Rattus norvegicus)	BDBM50258205 (2-(4-tert-butylphenyl)-4-(4-((1-ethyl-5-methyl-1H-...) Show SMILES Show InChI	KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	200	n/a	n/a	n/a	n/a	n/a	n/a
Wyeth Research Curated by ChEMBL					Assay Description Antagonist activity at GNRH receptor in rat pituitary cells assessed as inhibition of D-Trp6-GnRH-induced LH accumulation after 3 hrs by RIA				Bioorg Med Chem Lett 20: 2512-5 (2010) Article DOI: 10.1016/j.bmcl.2010.02.099 BindingDB Entry DOI: 10.7270/Q2W0962G
Wyeth Research Curated by ChEMBL					More data for this Ligand-Target Pair