Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Growth hormone-releasing hormone receptor' and Ligand = 'BDBM50004969'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Growth hormone-releasing hormone receptor (Rattus norvegicus)	BDBM50004969 (CHEMBL266658 | GRF-analogues) Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O Show InChI InChI=1S/C144H237N43O41/c1-19-74(13)112(185-118(205)78(17)163-127(214)100(63-109(198)199)172-117(204)76(15)162-119(206)85(147)59-81-38-42-83(192)43-39-81)139(226)179-98(60-80-31-22-21-23-32-80)133(220)187-114(79(18)191)141(228)180-99(62-107(150)196)132(219)182-103(67-189)137(224)176-97(61-82-40-44-84(193)45-41-82)131(218)170-90(37-30-54-160-144(156)157)122(209)169-88(34-25-27-51-146)126(213)184-111(73(11)12)138(225)178-93(55-69(3)4)120(207)161-65-108(197)165-91(46-48-105(148)194)124(211)174-96(58-72(9)10)130(217)181-102(66-188)135(222)164-77(16)116(203)167-89(36-29-53-159-143(154)155)121(208)168-87(33-24-26-50-145)123(210)173-95(57-71(7)8)129(216)175-94(56-70(5)6)128(215)171-92(47-49-106(149)195)125(212)177-101(64-110(200)201)134(221)186-113(75(14)20-2)140(227)183-104(68-190)136(223)166-86(115(151)202)35-28-52-158-142(152)153/h21-23,31-32,38-45,69-79,85-104,111-114,188-193H,19-20,24-30,33-37,46-68,145-147H2,1-18H3,(H2,148,194)(H2,149,195)(H2,150,196)(H2,151,202)(H,161,207)(H,162,206)(H,163,214)(H,164,222)(H,165,197)(H,166,223)(H,167,203)(H,168,208)(H,169,209)(H,170,218)(H,171,215)(H,172,204)(H,173,210)(H,174,211)(H,175,216)(H,176,224)(H,177,212)(H,178,225)(H,179,226)(H,180,228)(H,181,217)(H,182,219)(H,183,227)(H,184,213)(H,185,205)(H,186,221)(H,187,220)(H,198,199)(H,200,201)(H4,152,153,158)(H4,154,155,159)(H4,156,157,160)/t74-,75-,76-,77-,78-,79+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,111-,112-,113-,114-/m0/s1	Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	9.5	n/a	n/a	n/a	n/a	n/a	n/a
Notre-Dame Hospital Research Curated by ChEMBL					Assay Description Compound was tested to Inhibit [125I]-Growth hormone-releasing factor in rat adenopituitary homogenates				J Med Chem 35: 1864-9 (1992) BindingDB Entry DOI: 10.7270/Q2Z0373P
					More data for this Ligand-Target Pair