Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1' and Ligand = 'BDBM280794'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM280794 (3-(3-{4-amino-2-[6-fluoro-1- (2-fluorobenzyl)-1H-i...) Show SMILES CC1(C(=O)Nc2nc(nc(N)c12)-c1nn(Cc2ccccc2F)c2cc(F)ccc12)c1cccc(CCC(O)=O)c1 Show InChI InChI=1S/C30H24F2N6O3/c1-30(18-7-4-5-16(13-18)9-12-23(39)40)24-26(33)34-28(35-27(24)36-29(30)41)25-20-11-10-19(31)14-22(20)38(37-25)15-17-6-2-3-8-21(17)32/h2-8,10-11,13-14H,9,12,15H2,1H3,(H,39,40)(H3,33,34,35,36,41)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0660	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...				US Patent US10030027 (2018) BindingDB Entry DOI: 10.7270/Q22N549C
					More data for this Ligand-Target Pair