Found 2 hits Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1' and Ligand = 'BDBM280851' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Guanylate cyclase soluble subunit alpha-1
(Homo sapiens (Human)) | BDBM280851
(3-{2-[4-amino-2-{6- chloro-1-[4- methylcyclohexylm...)Show SMILES CC1CCC(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3ccc(Cl)cc23)CC1 |(-1.39,-7.53,;-2.48,-6.44,;-3.97,-6.84,;-5.06,-5.75,;-4.66,-4.26,;-5.75,-3.17,;-5.35,-1.69,;-3.89,-1.21,;-3.89,.33,;-2.55,1.1,;-1.22,.33,;.11,1.1,;1.58,.62,;2.48,1.87,;4.02,1.87,;1.58,3.12,;.81,4.45,;2.91,3.89,;4.38,3.41,;5.28,4.66,;6.82,4.66,;7.59,5.99,;7.59,7.53,;6.26,6.76,;9.13,5.99,;9.9,7.32,;9.9,4.66,;4.38,5.9,;2.91,5.43,;.11,2.64,;-1.22,3.41,;-1.22,4.95,;-2.55,2.64,;-5.35,.81,;-5.98,2.21,;-7.51,2.37,;-8.41,1.13,;-9.9,1.53,;-7.79,-.28,;-6.26,-.44,;-3.17,-3.86,;-2.08,-4.95,)| Show InChI InChI=1S/C30H34ClN7O4/c1-15-5-7-16(8-6-15)13-38-20-11-17(31)9-10-19(20)22(37-38)25-34-23(32)21-24(35-25)36-26(39)30(21,4)27-33-18(14-42-27)12-29(2,3)28(40)41/h9-11,14-16H,5-8,12-13H2,1-4H3,(H,40,41)(H3,32,34,35,36,39) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 0.0740 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi... |
US Patent US10030027 (2018)
BindingDB Entry DOI: 10.7270/Q22N549C |
More data for this Ligand-Target Pair | |
Guanylate cyclase soluble subunit alpha-1
(Homo sapiens (Human)) | BDBM280851
(3-{2-[4-amino-2-{6- chloro-1-[4- methylcyclohexylm...)Show SMILES CC1CCC(Cn2nc(-c3nc4NC(=O)C(C)(c5nc(CC(C)(C)C(O)=O)co5)c4c(N)n3)c3ccc(Cl)cc23)CC1 |(-1.39,-7.53,;-2.48,-6.44,;-3.97,-6.84,;-5.06,-5.75,;-4.66,-4.26,;-5.75,-3.17,;-5.35,-1.69,;-3.89,-1.21,;-3.89,.33,;-2.55,1.1,;-1.22,.33,;.11,1.1,;1.58,.62,;2.48,1.87,;4.02,1.87,;1.58,3.12,;.81,4.45,;2.91,3.89,;4.38,3.41,;5.28,4.66,;6.82,4.66,;7.59,5.99,;7.59,7.53,;6.26,6.76,;9.13,5.99,;9.9,7.32,;9.9,4.66,;4.38,5.9,;2.91,5.43,;.11,2.64,;-1.22,3.41,;-1.22,4.95,;-2.55,2.64,;-5.35,.81,;-5.98,2.21,;-7.51,2.37,;-8.41,1.13,;-9.9,1.53,;-7.79,-.28,;-6.26,-.44,;-3.17,-3.86,;-2.08,-4.95,)| Show InChI InChI=1S/C30H34ClN7O4/c1-15-5-7-16(8-6-15)13-38-20-11-17(31)9-10-19(20)22(37-38)25-34-23(32)21-24(35-25)36-26(39)30(21,4)27-33-18(14-42-27)12-29(2,3)28(40)41/h9-11,14-16H,5-8,12-13H2,1-4H3,(H,40,41)(H3,32,34,35,36,39) | PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| US Patent
| 0.105 | n/a | n/a | n/a | n/a | n/a | n/a | 7.4 | n/a |
Merck Sharp & Dohme Corp.
US Patent
| Assay Description The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi... |
US Patent US10030027 (2018)
BindingDB Entry DOI: 10.7270/Q22N549C |
More data for this Ligand-Target Pair | |