Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Guanylate cyclase soluble subunit alpha-1' and Ligand = 'BDBM280884'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Guanylate cyclase soluble subunit alpha-1 (Homo sapiens (Human))	BDBM280884 ((S)-3-(4-{4-amino- 2-[6-chloro-1- (cyclopentylmeth...) Show SMILES C[C@]1(C(=O)Nc2nc(nc(N)c12)-c1nn(CC2CCCC2)c2cc(Cl)ccc12)c1ccc(CCC(O)=O)cc1 |r| Show InChI InChI=1S/C29H29ClN6O3/c1-29(18-9-6-16(7-10-18)8-13-22(37)38)23-25(31)32-27(33-26(23)34-28(29)39)24-20-12-11-19(30)14-21(20)36(35-24)15-17-4-2-3-5-17/h6-7,9-12,14,17H,2-5,8,13,15H2,1H3,(H,37,38)(H3,31,32,33,34,39)/t29-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	0.0620	n/a	n/a	n/a	n/a	n/a	n/a	7.4	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The binding potencies of sGC compounds to the human recombinant sGC enzyme were determined in a Size Exclusion Chromatography (SEC) competition bindi...				US Patent US10030027 (2018) BindingDB Entry DOI: 10.7270/Q22N549C
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