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Found 1 hit Enz. Inhib. hit(s) with Target = 'HIV WT-B pol protein (wild-type clade B)' and Ligand = 'BDBM577'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV WT-B pol protein (wild-type clade B)


(Human immunodeficiency virus)
BDBM577
PNG
((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Show SMILES CC(C)CN(C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)O[C@H]1CCOC1)S(=O)(=O)c1ccc(N)cc1 |r|
Show InChI InChI=1S/C25H35N3O6S/c1-18(2)15-28(35(31,32)22-10-8-20(26)9-11-22)16-24(29)23(14-19-6-4-3-5-7-19)27-25(30)34-21-12-13-33-17-21/h3-11,18,21,23-24,29H,12-17,26H2,1-2H3,(H,27,30)/t21-,23-,24+/m0/s1
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Article
PubMed
n/an/an/an/a 1.80n/an/an/an/a



Massachusetts Institute of Technology



Assay Description
Drug susceptibility assays were carried out by Monogram Bioscience against wild-type HIV-1 control and patient-derived strains of wild-type HIV-1 fro...


ACS Chem Biol 8: 2433-41 (2013)


Article DOI: 10.1021/cb400468c
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)