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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'HIV-1 Reverse Transcriptase RNase H' and Ligand = 'BDBM33957'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
HIV-1 Reverse Transcriptase RNase H


(Human immunodeficiency virus type 1)
BDBM33957
PNG
(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C21H21N3O2/c1-24(2)17-11-8-16(9-12-17)21(25)23-22-14-19-18-7-5-4-6-15(18)10-13-20(19)26-3/h4-14H,1-3H3,(H,23,25)/b22-14+
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2.00E+3n/an/an/an/a8.037



Rutgers University



Assay Description
To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...


ACS Chem Biol 1: 702-12 (2006)


Article DOI: 10.1021/cb600303y
More data for this
Ligand-Target Pair
HIV-1 Reverse Transcriptase RNase H


(Human immunodeficiency virus type 1)
BDBM33957
PNG
(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)
Show SMILES COc1ccc2ccccc2c1\C=N\NC(=O)c1ccc(cc1)N(C)C
Show InChI InChI=1S/C21H21N3O2/c1-24(2)17-11-8-16(9-12-17)21(25)23-22-14-19-18-7-5-4-6-15(18)10-13-20(19)26-3/h4-14H,1-3H3,(H,23,25)/b22-14+
PDB
MMDB

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a>5.00E+4n/an/an/an/a7.837



Rutgers University



Assay Description
HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...


ACS Chem Biol 1: 702-12 (2006)


Article DOI: 10.1021/cb600303y
More data for this
Ligand-Target Pair