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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM24754'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24754
PNG
(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(4-methylp...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C36H38FN5O4/c1-40-15-17-42(18-16-40)14-7-19-45-34-23-30-27(22-33(34)44-3)31(12-13-38-30)46-32-11-10-26(21-29(32)37)28-24-39-35(41(2)36(28)43)20-25-8-5-4-6-9-25/h4-6,8-13,21-24H,7,14-20H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
9.20 -45.4n/an/an/an/an/a7.522



Amgen



Assay Description
In vitro kinase assays were done to establish IC50 values against recombinant enzymes using homogeneous time-resolved fluorescence (HTRF) assay. For ...


J Med Chem 51: 5766-79 (2008)


Article DOI: 10.1021/jm8006189
BindingDB Entry DOI: 10.7270/Q23X84XN
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM24754
PNG
(2-benzyl-5-[3-fluoro-4-({6-methoxy-7-[3-(4-methylp...)
Show SMILES COc1cc2c(Oc3ccc(cc3F)-c3cnc(Cc4ccccc4)n(C)c3=O)ccnc2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C36H38FN5O4/c1-40-15-17-42(18-16-40)14-7-19-45-34-23-30-27(22-33(34)44-3)31(12-13-38-30)46-32-11-10-26(21-29(32)37)28-24-39-35(41(2)36(28)43)20-25-8-5-4-6-9-25/h4-6,8-13,21-24H,7,14-20H2,1-3H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/a 9.20n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair