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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM28027'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28027
PNG
(2-aminopyridine analogue, 6 | N-(4-{[2-amino-3-(hy...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1CO
Show InChI InChI=1S/C24H18F2N4O4/c25-14-3-6-16(7-4-14)30-11-1-2-17(24(30)33)23(32)29-15-5-8-21(19(26)12-15)34-20-9-10-28-22(27)18(20)13-31/h1-12,31H,13H2,(H2,27,28)(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.40n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of human c-MET


Eur J Med Chem 46: 3675-80 (2011)


Article DOI: 10.1016/j.ejmech.2011.05.031
BindingDB Entry DOI: 10.7270/Q2891676
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM28027
PNG
(2-aminopyridine analogue, 6 | N-(4-{[2-amino-3-(hy...)
Show SMILES Nc1nccc(Oc2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c1CO
Show InChI InChI=1S/C24H18F2N4O4/c25-14-3-6-16(7-4-14)30-11-1-2-17(24(30)33)23(32)29-15-5-8-21(19(26)12-15)34-20-9-10-28-22(27)18(20)13-31/h1-12,31H,13H2,(H2,27,28)(H,29,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 3.40n/an/an/an/a7.530



Bristol-Myers Squibb Company



Assay Description
Kinase activity was assayed using baculovirus expressed GST-Met, and poly(Glu/Tyr) as the substrate in the presence of test compound. Dose response c...


J Med Chem 52: 1251-4 (2009)


Article DOI: 10.1021/jm801586s
BindingDB Entry DOI: 10.7270/Q20863MZ
More data for this
Ligand-Target Pair