new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50182528'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50182528
PNG
(CHEMBL3818743 | US9512121, 7)
Show SMILES [H][C@@]12CCCN1c1cnc3ccc(Sc4nnc5c(F)cc(cn45)-c4cnn(C)c4)cc3c1OC2 |r|
Show InChI InChI=1/C24H20FN7OS/c1-30-11-15(9-27-30)14-7-19(25)23-28-29-24(32(23)12-14)34-17-4-5-20-18(8-17)22-21(10-26-20)31-6-2-3-16(31)13-33-22/h4-5,7-12,16H,2-3,6,13H2,1H3/t16-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
US Patent
n/an/a 123n/an/an/an/an/a20



Jiangsu Hansoh Pharmaceutical Co., Ltd.

US Patent


Assay Description
Experimental Purpose: The purpose is to study the effect of the compounds on c-MET tyrosine kinase activity at the molecular level. IC50 values were ...


US Patent US9512121 (2016)


BindingDB Entry DOI: 10.7270/Q2ST7NSV
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50182528
PNG
(CHEMBL3818743 | US9512121, 7)
Show SMILES [H][C@@]12CCCN1c1cnc3ccc(Sc4nnc5c(F)cc(cn45)-c4cnn(C)c4)cc3c1OC2 |r|
Show InChI InChI=1/C24H20FN7OS/c1-30-11-15(9-27-30)14-7-19(25)23-28-29-24(32(23)12-14)34-17-4-5-20-18(8-17)22-21(10-26-20)31-6-2-3-16(31)13-33-22/h4-5,7-12,16H,2-3,6,13H2,1H3/t16-/s2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
PubMed
n/an/a 123n/an/an/an/an/an/a



Southeast University

Curated by ChEMBL


Assay Description
Inhibition of c-Met (unknown origin) incubated for 1 hr by spectrophotometric analysis


Bioorg Med Chem 24: 3483-93 (2016)


BindingDB Entry DOI: 10.7270/Q29G5PQT
More data for this
Ligand-Target Pair