Found 7 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50317323' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 12 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc. / ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of human c-Met |
Bioorg Med Chem Lett 25: 3706-10 (2015)
Article DOI: 10.1016/j.bmcl.2015.06.034
BindingDB Entry DOI: 10.7270/Q2SJ1NDW |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met |
Bioorg Med Chem Lett 20: 2745-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met-mediated cell migration of human A549 cells by would healing |
Bioorg Med Chem Lett 20: 2745-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 500 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells |
Bioorg Med Chem Lett 20: 2745-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 2.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
MethylGene Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met-mediated scattering in HGF-stimulated human DU145 cells |
Bioorg Med Chem Lett 20: 2745-9 (2010)
Article DOI: 10.1016/j.bmcl.2010.03.073
BindingDB Entry DOI: 10.7270/Q24T6JJ6 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Laboratoires ChemRF Inc./ChemRF Laboratories Inc.
Curated by ChEMBL
| Assay Description
Inhibition of c-Met phosphorylation in human MKN45 cells |
Bioorg Med Chem Lett 25: 3810-5 (2015)
Article DOI: 10.1016/j.bmcl.2015.07.080
BindingDB Entry DOI: 10.7270/Q2028T99 |
More data for this
Ligand-Target Pair | |
Hepatocyte growth factor receptor
(Homo sapiens (Human)) | BDBM50317323
(CHEMBL1094718 | N-(3-fluoro-4-(2-(1-methyl-1H-imid...)Show SMILES Cn1cnc(c1)-c1cc2nccc(Oc3ccc(NC(=O)c4cnn(c4C(F)(F)F)-c4ccccc4)cc3F)c2s1 Show InChI InChI=1S/C28H18F4N6O2S/c1-37-14-21(34-15-37)24-12-20-25(41-24)23(9-10-33-20)40-22-8-7-16(11-19(22)29)36-27(39)18-13-35-38(26(18)28(30,31)32)17-5-3-2-4-6-17/h2-15H,1H3,(H,36,39) | PDB
MMDB
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| Purchase
CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 6.87E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
ChemRF Laboratories
Curated by ChEMBL
| Assay Description
Inhibition of phosphorylation of c-Met in human MKN45 cells |
Bioorg Med Chem Lett 25: 2527-31 (2015)
Article DOI: 10.1016/j.bmcl.2015.04.056
BindingDB Entry DOI: 10.7270/Q21C1ZMR |
More data for this
Ligand-Target Pair | |
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