Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM98029'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98029 (US10472367, Compound Formula III | US10919901, Com...) Show SMILES C[C@H](NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1)c1noc(C)n1 |r| Show InChI InChI=1S/C27H21ClN8O2/c1-15(25-33-16(2)38-35-25)32-26(37)21-7-6-19(12-22(21)28)24-14-31-27-30-13-20(36(27)34-24)11-17-5-8-23-18(10-17)4-3-9-29-23/h3-10,12-15H,11H2,1-2H3,(H,32,37)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.5	30
Incyte Corporation US Patent					Assay Description The compounds of the intervention were screened in vitro for their ability to inhibit c-Met kinase activity.				US Patent US8487096 (2013) BindingDB Entry DOI: 10.7270/Q2319THZ
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98029 (US10472367, Compound Formula III | US10919901, Com...) Show SMILES C[C@H](NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1)c1noc(C)n1 |r| Show InChI InChI=1S/C27H21ClN8O2/c1-15(25-33-16(2)38-35-25)32-26(37)21-7-6-19(12-22(21)28)24-14-31-27-30-13-20(36(27)34-24)11-17-5-8-23-18(10-17)4-3-9-29-23/h3-10,12-15H,11H2,1-2H3,(H,32,37)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-Met...				US Patent US10919901 (2021) BindingDB Entry DOI: 10.7270/Q2B85C72
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98029 (US10472367, Compound Formula III | US10919901, Com...) Show SMILES C[C@H](NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1)c1noc(C)n1 |r| Show InChI InChI=1S/C27H21ClN8O2/c1-15(25-33-16(2)38-35-25)32-26(37)21-7-6-19(12-22(21)28)24-14-31-27-30-13-20(36(27)34-24)11-17-5-8-23-18(10-17)4-3-9-29-23/h3-10,12-15H,11H2,1-2H3,(H,32,37)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	n/a	n/a
INCYTE INCORPORATION; INCYTE HOLDINGS CORPORATION US Patent					Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. Briefly, histidine-tagged c-Met catalytic d...				US Patent US10472367 (2019) BindingDB Entry DOI: 10.7270/Q2639S3S
					More data for this Ligand-Target Pair
Hepatocyte growth factor receptor (Homo sapiens (Human))	BDBM98029 (US10472367, Compound Formula III | US10919901, Com...) Show SMILES C[C@H](NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1)c1noc(C)n1 |r| Show InChI InChI=1S/C27H21ClN8O2/c1-15(25-33-16(2)38-35-25)32-26(37)21-7-6-19(12-22(21)28)24-14-31-27-30-13-20(36(27)34-24)11-17-5-8-23-18(10-17)4-3-9-29-23/h3-10,12-15H,11H2,1-2H3,(H,32,37)/t15-/m0/s1	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.550	n/a	n/a	n/a	n/a	7.5	30
Incyte Holdings Corporation; Incyte Corporation US Patent					Assay Description The compounds of the invention were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values for the inhibition of c-M...				US Patent US9221824 (2015) BindingDB Entry DOI: 10.7270/Q2MP524M
					More data for this Ligand-Target Pair