Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM135037'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM135037 (US8846698, 520) Show SMILES CC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cc3ccc(cc3)C#N)c2)c2cnc(N)nc12 Show InChI InChI=1S/C25H23N7O2/c1-25(2,3)32-14-20(19-13-29-24(27)31-23(19)32)22(34)17-9-18(12-28-11-17)30-21(33)8-15-4-6-16(10-26)7-5-15/h4-7,9,11-14H,8H2,1-3H3,(H,30,33)(H2,27,29,31)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	4.57	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...				US Patent US8846698 (2014) BindingDB Entry DOI: 10.7270/Q2F47MTW
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