Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM135053'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM135053 (US8846698, 538) Show SMILES COCC(C)(C)n1cc(C(=O)c2cncc(NC(=O)Cn3ccc(n3)C3CC3)c2)c2cncnc12 Show InChI InChI=1S/C25H27N7O3/c1-25(2,14-35-3)32-12-20(19-11-27-15-28-24(19)32)23(34)17-8-18(10-26-9-17)29-22(33)13-31-7-6-21(30-31)16-4-5-16/h6-12,15-16H,4-5,13-14H2,1-3H3,(H,29,33)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	1.51	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Limited US Patent					Assay Description Isolated TRK Enzyme assays use the HTRF KinEASE-TK kit (Cisbio Cat# 62TK0PEJ) with recombinant His-tagged cytoplasmic domains of each TRK receptor so...				US Patent US8846698 (2014) BindingDB Entry DOI: 10.7270/Q2F47MTW
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