Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'High affinity nerve growth factor receptor' and Ligand = 'BDBM356080'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
High affinity nerve growth factor receptor (Homo sapiens (Human))	BDBM356080 (US9815846, Compound 80) Show SMILES Cn1ccc(n1)-c1cc(C(=O)Nc2cnc(COC(N)=O)nc2-c2ccccc2)c(F)cc1C(F)(F)F Show InChI InChI=1S/C24H18F4N6O3/c1-34-8-7-18(33-34)14-9-15(17(25)10-16(14)24(26,27)28)22(35)31-19-11-30-20(12-37-23(29)36)32-21(19)13-5-3-2-4-6-13/h2-11H,12H2,1H3,(H2,29,36)(H,31,35)	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	0.490	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description TrkA functional activity was measured using a DiscoverX PathHunter assay. In this assay, U2OS cells express the human TrkA receptor as a fusion with ...				US Patent US9815846 (2017) BindingDB Entry DOI: 10.7270/Q20P129R
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