Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | 6.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Southmead Hospital Curated by ChEMBL | Assay Description Displacement of [125I]NGF from full length human TrkA expressed in HEKN3S cells cells by gamma counting based radioligand competition assay | J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 1.80E+6 | n/a | n/a | n/a | n/a | n/a |
Southmead Hospital Curated by ChEMBL | Assay Description Binding affinity to T292 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopy | J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.10E+6 | n/a | n/a | n/a | n/a | n/a |
Southmead Hospital Curated by ChEMBL | Assay Description Binding affinity to C345 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopy | J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.10E+6 | n/a | n/a | n/a | n/a | n/a |
Southmead Hospital Curated by ChEMBL | Assay Description Binding affinity to V305 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopy | J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | n/a | 8.60E+4 | n/a | n/a | n/a | n/a |
Southmead Hospital Curated by ChEMBL | Assay Description Antagonist activity at full length glycosylated human TrkA expressed in HEKN3S cells cells assessed as reduction in NGF-induced ERK 42/44 phosphoryla... | J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity nerve growth factor receptor (Homo sapiens (Human)) | BDBM50020712 (10,11-dihydro-5-(gamma-dimethylaminopropylidene)-5...) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL DrugBank MCE KEGG MMDB PC cid PC sid PDB UniChem Patents Similars | Article PubMed | n/a | n/a | n/a | 2.20E+6 | n/a | n/a | n/a | n/a | n/a |
Southmead Hospital Curated by ChEMBL | Assay Description Binding affinity to F303 residue of human recombinant TrkAIg2-NMR construct expressed in Escherichia coli by 1H-15N HSQC NMR spectroscopy | J Med Chem 58: 767-77 (2015) Article DOI: 10.1021/jm501307e BindingDB Entry DOI: 10.7270/Q25B045H | |||||||||||
More data for this Ligand-Target Pair |