BindingDB PrimarySearch

Found 22 hits Enz. Inhib. hit(s) with Target = 'Histamine H2 receptor' and Ligand = 'BDBM7966'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Histamine H2 receptor (RAT)	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	17	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Boehringer Ingelheim Italia Curated by PDSP K_i Database									Naunyn Schmiedebergs Arch Pharmacol 352: 276-82 (1995) Article DOI: 10.1007/bf00168557 BindingDB Entry DOI: 10.7270/Q2Q52N48
Boehringer Ingelheim Italia Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	100	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Queen's Medical Centre Curated by PDSP K_i Database									Biochem Soc Trans 20: 122-5 (1992) Article DOI: 10.1042/bst0200122 BindingDB Entry DOI: 10.7270/Q2RX99KH
Queen's Medical Centre Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by PDSP K_i Database									J Pharmacol Exp Ther 317: 1262-8 (2006) Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ
University of Kansas Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Kansas Curated by PDSP K_i Database									J Pharmacol Exp Ther 317: 1262-8 (2006) Article DOI: 10.1124/jpet.106.102897 BindingDB Entry DOI: 10.7270/Q2X63KHZ
University of Kansas Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Hoechst Pharmaceutical Research Laboratories Curated by PDSP K_i Database									Nature 304: 65-7 (1983) Article DOI: 10.1038/304065a0 BindingDB Entry DOI: 10.7270/Q2930RN2
					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by PDSP K_i Database									Eur J Pharmacol 487: 183-97 (2004) Article DOI: 10.1016/j.ejphar.2004.01.015 BindingDB Entry DOI: 10.7270/Q2NZ866C
Abbott Laboratories Curated by PDSP K_i Database					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at human H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay				J Med Chem 55: 1147-60 (2012) Article DOI: 10.1021/jm201128q BindingDB Entry DOI: 10.7270/Q2HQ411W
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	n/a	6.92E+4	n/a	n/a	n/a	n/a	n/a
Vrije Universiteit Curated by ChEMBL					Assay Description Compound is evaluated for histamine H2 receptor agonistic activity in guinea pig cerebral cortex using [3H]tiotidine as radioligand				J Med Chem 35: 3239-46 (1992) BindingDB Entry DOI: 10.7270/Q2C53N4J
Vrije Universiteit Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (RAT)	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB KEGG UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article	n/a	n/a	n/a	1.17E+5	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Affinity to the Histamine H2 receptor was determined expressed in CHO cell using [125I]iodoaminopotentidine as radioligand				Bioorg Med Chem Lett 4: 1913-1916 (1994) Article DOI: 10.1016/S0960-894X(01)80533-3 BindingDB Entry DOI: 10.7270/Q2TD9ZHX
TBA Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Activity at human recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Activity at guinea pig recombinant histamine H2 receptor-Gsalpha fusion protein expressed in Sf9 cells by steady-state GTPase activity assay				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at histamine H2 receptor in guinea pig spontaneously beating right atrium assessed as positive chronotropic activity				J Med Chem 51: 7193-204 (2009) Article DOI: 10.1021/jm800841w BindingDB Entry DOI: 10.7270/Q2RN38T6
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at human histamine H2 receptor expressed in Sf9 cells coexpressing GsalphaS protein by steady-state GTPase assay				J Med Chem 52: 6297-313 (2009) Article DOI: 10.1021/jm900526h BindingDB Entry DOI: 10.7270/Q2PN96VG
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at histamine H2 receptor in spontaneously beating guinea pig atrium				Bioorg Med Chem Lett 20: 3173-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.082 BindingDB Entry DOI: 10.7270/Q2RF5W9M
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.26E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at GsalphaS-fused human histamine H2 receptor expressed in Sf9 cells by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 20: 3173-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.082 BindingDB Entry DOI: 10.7270/Q2RF5W9M
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at guinea pig H2R-Gsalphas expressed in Sf9 cells at 0.1 nM to 10 uM by steady state GTPase activity assay				J Med Chem 55: 1147-60 (2012) Article DOI: 10.1021/jm201128q BindingDB Entry DOI: 10.7270/Q2HQ411W
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at GsalphaS-fused guinea pig histamine H2 receptor expressed in Sf9 cells by [35S]GTPgammaS binding assay				Bioorg Med Chem Lett 20: 3173-6 (2010) Article DOI: 10.1016/j.bmcl.2010.03.082 BindingDB Entry DOI: 10.7270/Q2RF5W9M
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	650	n/a	n/a	n/a	n/a
Hokkaido University Curated by ChEMBL					Assay Description Agonist activity at human H2 receptor expressed in 293-EBNA cells by luciferase reporter gene assay				J Med Chem 49: 5587-96 (2006) Article DOI: 10.1021/jm0603318 BindingDB Entry DOI: 10.7270/Q2MW2GRK
Hokkaido University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	463	n/a	n/a	n/a	n/a
Hokkaido University Curated by ChEMBL					Assay Description Inhibition of human Histamine H2 receptor using [3H]-tiotidine				J Med Chem 46: 1980-8 (2003) Article DOI: 10.1021/jm020415q BindingDB Entry DOI: 10.7270/Q2XG9QG6
Hokkaido University Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at histamine H2 receptor in guinea pig atrium assessed as increase in heart rate				J Med Chem 52: 2623-7 (2009) Article DOI: 10.1021/jm9000693 BindingDB Entry DOI: 10.7270/Q2P270BN
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Homo sapiens (Human))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	DrugBank Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at human H2 receptor expressed in insect Sf9 cells co-expressing GsalphaS fusion protein assessed as gamma[32P]GTP binding by liquid...				J Med Chem 52: 2623-7 (2009) Article DOI: 10.1021/jm9000693 BindingDB Entry DOI: 10.7270/Q2P270BN
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair
Histamine H2 receptor (Cavia porcellus (domestic guinea pig))	BDBM7966 (2-(1H-imidazol-4-yl)ethan-1-amine \| CHEMBL544208 \|...) Show SMILES NCCc1cnc[nH]1 Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE MMDB PC cid PC sid PDB UniChem Patents Similars	Article PubMed	n/a	n/a	n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a
University of Regensburg Curated by ChEMBL					Assay Description Agonist activity at H2R in spontaneously beating guinea pig right atrium assessed as increase in heart rate				J Med Chem 55: 1147-60 (2012) Article DOI: 10.1021/jm201128q BindingDB Entry DOI: 10.7270/Q2HQ411W
University of Regensburg Curated by ChEMBL					More data for this Ligand-Target Pair