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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Histamine H4 receptor' and Ligand = 'BDBM50362216'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50362216
PNG
(CHEMBL1938977)
Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2ccc(F)cc2[nH]1 |r|
Show InChI InChI=1S/C15H18FN5/c1-20-5-9-7-21(8-10(9)6-20)14(17)15-18-12-3-2-11(16)4-13(12)19-15/h2-4,9-10,17H,5-8H2,1H3,(H,18,19)/t9-,10+
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Similars

Article
PubMed
4.60n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Displacement of [3H]histamine from human recombinant histamine H4 receptor expressed in CHO cells coexpressing Ga15 by radioligand filtration binding...


Bioorg Med Chem Lett 22: 1156-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.098
BindingDB Entry DOI: 10.7270/Q2Q81DJD
More data for this
Ligand-Target Pair
Histamine H4 receptor


(Homo sapiens (Human))
BDBM50362216
PNG
(CHEMBL1938977)
Show SMILES CN1C[C@H]2CN(C[C@H]2C1)C(=N)c1nc2ccc(F)cc2[nH]1 |r|
Show InChI InChI=1S/C15H18FN5/c1-20-5-9-7-21(8-10(9)6-20)14(17)15-18-12-3-2-11(16)4-13(12)19-15/h2-4,9-10,17H,5-8H2,1H3,(H,18,19)/t9-,10+
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
9.10n/an/an/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Antagonist activity at human histamine H4 receptor expressed in HEK293 cells assessed as rev inhibition of forskolin-stimulated cAMP accumulation by ...


Bioorg Med Chem Lett 22: 1156-9 (2012)


Article DOI: 10.1016/j.bmcl.2011.11.098
BindingDB Entry DOI: 10.7270/Q2Q81DJD
More data for this
Ligand-Target Pair