new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Histamine receptor (H3)' and Ligand = 'BDBM50327480'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50327480
PNG
((R)-8-(3-(2-methylpyrrolidin-1-yl)propoxy)-3,4-dih...)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc2n3CCNC(=O)c3cc2c1 |r|
Show InChI InChI=1S/C19H25N3O2/c1-14-4-2-8-21(14)9-3-11-24-16-5-6-17-15(12-16)13-18-19(23)20-7-10-22(17)18/h5-6,12-14H,2-4,7-11H2,1H3,(H,20,23)/t14-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
7n/an/an/an/an/an/an/an/a



F Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Displacement of [3H]-RAMH from human histamine H3 receptor


Bioorg Med Chem Lett 20: 5713-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.009
BindingDB Entry DOI: 10.7270/Q2571C7N
More data for this
Ligand-Target Pair
Histamine receptor (H3)


(Homo sapiens (Human))
BDBM50327480
PNG
((R)-8-(3-(2-methylpyrrolidin-1-yl)propoxy)-3,4-dih...)
Show SMILES C[C@@H]1CCCN1CCCOc1ccc2n3CCNC(=O)c3cc2c1 |r|
Show InChI InChI=1S/C19H25N3O2/c1-14-4-2-8-21(14)9-3-11-24-16-5-6-17-15(12-16)13-18-19(23)20-7-10-22(17)18/h5-6,12-14H,2-4,7-11H2,1H3,(H,20,23)/t14-/m1/s1
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 4n/an/an/an/a



F Hoffmann-La Roche Ltd

Curated by ChEMBL


Assay Description
Inverse agonist activity at human recombinant histamine H3 receptor assessed as effect on [35S]GTPgammaS binding


Bioorg Med Chem Lett 20: 5713-7 (2010)


Article DOI: 10.1016/j.bmcl.2010.08.009
BindingDB Entry DOI: 10.7270/Q2571C7N
More data for this
Ligand-Target Pair