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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone deacetylase 1' and Ligand = 'BDBM50151377'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 1


(Homo sapiens (Human))		BDBM50151377
PNG
(CHEMBL3774890)
Show SMILES COc1ccc(cc1OCCCCCC(=O)NO)N(C)c1nc(C)nc2ccccc12
Show InChI InChI=1S/C23H28N4O4/c1-16-24-19-10-7-6-9-18(19)23(25-16)27(2)17-12-13-20(30-3)21(15-17)31-14-8-4-5-11-22(28)26-29/h6-7,9-10,12-13,15,29H,4-5,8,11,14H2,1-3H3,(H,26,28)
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n/an/a 160n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of KDM5B (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...

J Med Chem 59: 1455-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01342
BindingDB Entry DOI: 10.7270/Q2T155H3
More data for this
Ligand-Target Pair