Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50015088 ((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | US Patent | n/a | n/a | 725 | n/a | n/a | n/a | n/a | n/a | n/a |
The General Hospital Corporation US Patent | Assay Description All histone deacetylases were purchased from BPS Bioscience. The substrates, Broad Substrate A, and Broad Substrate B, were synthesized and are now a... | US Patent US10188756 (2019) BindingDB Entry DOI: 10.7270/Q20Z75CX | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone deacetylase 8 (Homo sapiens (Human)) | BDBM50015088 ((E)-N-Hydroxy-3-phenyl-acrylamide | (E)-N-Hydroxy-...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | Purchase CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 759 | n/a | n/a | n/a | n/a | n/a | 25 |
Broad Institute of MIT and Harvard Curated by ChEMBL | Assay Description Inhibition of HDAC8 (unknown origin) assessed as fluorescence intensity measured after 60 mins incubation at room temperature by trypsin-free microfl... | J Med Chem 56: 1772-6 (2013) Article DOI: 10.1021/jm301355j BindingDB Entry DOI: 10.7270/Q2XK8GWB | |||||||||||
More data for this Ligand-Target Pair |