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Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone deacetylase 8' and Ligand = 'BDBM50151374'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone deacetylase 8


(Homo sapiens (Human))		BDBM50151374
PNG
(CHEMBL3774877)
Show SMILES COc1ccc(cc1OCC(=O)NO)N(C)c1nc(C)nc2ccccc12
Show InChI InChI=1S/C19H20N4O4/c1-12-20-15-7-5-4-6-14(15)19(21-12)23(2)13-8-9-16(26-3)17(10-13)27-11-18(24)22-25/h4-10,25H,11H2,1-3H3,(H,22,24)
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MMDB

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Article
PubMed
n/an/a>1.00E+3n/an/an/an/an/an/a



Sichuan University

Curated by ChEMBL


Assay Description
Inhibition of KDM5C (unknown origin) using biotin-H3K4me3 as substrate preincubated for 15 mins followed by substrate addition measured after 20 mins...

J Med Chem 59: 1455-70 (2016)


Article DOI: 10.1021/acs.jmedchem.5b01342
BindingDB Entry DOI: 10.7270/Q2T155H3
More data for this
Ligand-Target Pair