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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM50063680'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Histone-lysine N-methyltransferase EZH2


(Homo sapiens (Human))		BDBM50063680
PNG
(CHEMBL3397319)
Show SMILES Cc1cc(CNC(=O)[C@@H](N)CCSC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c(N)ncnc23)n(C)n1 |r|
Show InChI InChI=1S/C20H29N9O4S/c1-10-5-11(28(2)27-10)6-23-19(32)12(21)3-4-34-7-13-15(30)16(31)20(33-13)29-9-26-14-17(22)24-8-25-18(14)29/h5,8-9,12-13,15-16,20,30-31H,3-4,6-7,21H2,1-2H3,(H,23,32)(H2,22,24,25)/t12-,13+,15+,16+,20+/m0/s1
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Similars
Article
PubMed
n/an/a 4.00E+4n/an/an/an/an/an/a



Pfizer Inc.

Curated by ChEMBL


Assay Description
Inhibition of N-terminally FLAG-tagged wild type EZH2 in EZH2/SUZ12/EED/RbAp48 complex (unknown origin) expressed in baculovirus infected in SF9 cell...

Bioorg Med Chem Lett 25: 1532-7 (2015)


Article DOI: 10.1016/j.bmcl.2015.02.017
BindingDB Entry DOI: 10.7270/Q2TM7CSS
More data for this
Ligand-Target Pair