Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM50110362'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50110362 (CHEMBL3605451) Show SMILES CCC(C)n1c(C)c(C(=O)NCc2c(C)cc(C)nc2O)c2ccccc12 Show InChI InChI=1S/C22H27N3O2/c1-6-15(4)25-16(5)20(17-9-7-8-10-19(17)25)22(27)23-12-18-13(2)11-14(3)24-21(18)26/h7-11,15H,6,12H2,1-5H3,(H,23,27)(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	14	n/a	n/a	n/a	n/a	n/a	n/a
Constellation Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EZH2 (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count based method				Bioorg Med Chem Lett 25: 3644-9 (2015) Article DOI: 10.1016/j.bmcl.2015.06.056 BindingDB Entry DOI: 10.7270/Q2Q24205
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50110362 (CHEMBL3605451) Show SMILES CCC(C)n1c(C)c(C(=O)NCc2c(C)cc(C)nc2O)c2ccccc12 Show InChI InChI=1S/C22H27N3O2/c1-6-15(4)25-16(5)20(17-9-7-8-10-19(17)25)22(27)23-12-18-13(2)11-14(3)24-21(18)26/h7-11,15H,6,12H2,1-5H3,(H,23,27)(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	118	n/a	n/a	n/a	n/a	n/a	n/a
Constellation Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EZH2 Y641N mutant (unknown origin) using biotinylated nucleosome, H3K27me3 activator and [3H]-SAM incubated for 60 mins by top-count ba...				Bioorg Med Chem Lett 25: 3644-9 (2015) Article DOI: 10.1016/j.bmcl.2015.06.056 BindingDB Entry DOI: 10.7270/Q2Q24205
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50110362 (CHEMBL3605451) Show SMILES CCC(C)n1c(C)c(C(=O)NCc2c(C)cc(C)nc2O)c2ccccc12 Show InChI InChI=1S/C22H27N3O2/c1-6-15(4)25-16(5)20(17-9-7-8-10-19(17)25)22(27)23-12-18-13(2)11-14(3)24-21(18)26/h7-11,15H,6,12H2,1-5H3,(H,23,27)(H,24,26)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	929	n/a	n/a	n/a	n/a	n/a	n/a
Constellation Pharmaceuticals, Inc. Curated by ChEMBL					Assay Description Inhibition of EZH2 in human HeLa cells assessed as reduction in H3K27me3 levels incubated for 72 hrs by ELISA method				Bioorg Med Chem Lett 25: 3644-9 (2015) Article DOI: 10.1016/j.bmcl.2015.06.056 BindingDB Entry DOI: 10.7270/Q2Q24205
					More data for this Ligand-Target Pair