Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM50149883'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50149883 (CHEMBL3770619) Show SMILES Cc1cc(C)c(CNC(=O)c2cc(Br)cc(NC3CCOCC3)c2C)c(=O)[nH]1 Show InChI InChI=1S/C21H26BrN3O3/c1-12-8-13(2)24-21(27)18(12)11-23-20(26)17-9-15(22)10-19(14(17)3)25-16-4-6-28-7-5-16/h8-10,16,25H,4-7,11H2,1-3H3,(H,23,26)(H,24,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
Epizyme Curated by ChEMBL					Assay Description Inhibition of methyltransferase activity of human EZH2 using chicken oligonucleotide as substrate by pull down assay				J Med Chem 59: 1556-64 (2016) Article DOI: 10.1021/acs.jmedchem.5b01501 BindingDB Entry DOI: 10.7270/Q2B56MM7
					More data for this Ligand-Target Pair