Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Histone-lysine N-methyltransferase EZH2' and Ligand = 'BDBM50193712'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50193712 (CHEMBL3919969) Show SMILES Cc1n[nH]c(C)c1-c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl |(45.66,-39.4,;45.34,-40.91,;46.37,-42.05,;45.6,-43.38,;44.09,-43.06,;42.95,-44.09,;43.93,-41.53,;42.59,-40.76,;41.26,-41.53,;39.94,-40.76,;38.61,-41.53,;39.95,-39.24,;38.62,-38.48,;38.62,-36.94,;39.95,-36.16,;39.95,-34.62,;38.61,-33.85,;38.62,-32.31,;39.96,-31.54,;37.29,-31.54,;35.96,-32.3,;34.63,-31.53,;35.95,-33.84,;37.29,-34.62,;37.29,-36.16,;41.28,-36.94,;42.61,-36.17,;41.28,-38.48,;42.59,-39.24,;43.93,-38.47,)| Show InChI InChI=1S/C22H22Cl2N4O2/c1-10-7-11(2)25-21(29)16(10)9-28-6-5-14-17(23)8-15(20(24)19(14)22(28)30)18-12(3)26-27-13(18)4/h7-8H,5-6,9H2,1-4H3,(H,25,29)(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	16	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of wild-type EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex using HeLa cells der...				J Med Chem 59: 8306-25 (2016) Article DOI: 10.1021/acs.jmedchem.6b00515 BindingDB Entry DOI: 10.7270/Q2J1053B
					More data for this Ligand-Target Pair
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human))	BDBM50193712 (CHEMBL3919969) Show SMILES Cc1n[nH]c(C)c1-c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl |(45.66,-39.4,;45.34,-40.91,;46.37,-42.05,;45.6,-43.38,;44.09,-43.06,;42.95,-44.09,;43.93,-41.53,;42.59,-40.76,;41.26,-41.53,;39.94,-40.76,;38.61,-41.53,;39.95,-39.24,;38.62,-38.48,;38.62,-36.94,;39.95,-36.16,;39.95,-34.62,;38.61,-33.85,;38.62,-32.31,;39.96,-31.54,;37.29,-31.54,;35.96,-32.3,;34.63,-31.53,;35.95,-33.84,;37.29,-34.62,;37.29,-36.16,;41.28,-36.94,;42.61,-36.17,;41.28,-38.48,;42.59,-39.24,;43.93,-38.47,)| Show InChI InChI=1S/C22H22Cl2N4O2/c1-10-7-11(2)25-21(29)16(10)9-28-6-5-14-17(23)8-15(20(24)19(14)22(28)30)18-12(3)26-27-13(18)4/h7-8H,5-6,9H2,1-4H3,(H,25,29)(H,26,27)	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	502	n/a	n/a	n/a	n/a	n/a	n/a
Pfizer Inc. Curated by ChEMBL					Assay Description Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27Me3 levels after 72 hrs by ELISA				J Med Chem 59: 8306-25 (2016) Article DOI: 10.1021/acs.jmedchem.6b00515 BindingDB Entry DOI: 10.7270/Q2J1053B
					More data for this Ligand-Target Pair