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Compile Data Set for Download or QSAR

Found 4 hits Enz. Inhib. hit(s) with Target = 'Hydroxycarboxylic acid receptor 2' and Ligand = 'BDBM50220842'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hydroxycarboxylic acid receptor 2


(Rattus norvegicus)
BDBM50220842
PNG
(3-butyl-1H-pyrazole-5-carboxylic acid | 5-butyl-1H...)
Show SMILES CCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
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PubMed
72n/an/an/an/an/an/an/an/a



Leiden/Amsterdam Center for Drug Research

Curated by ChEMBL


Assay Description
Inhibition of [3H]-nicotinic acid (20 nM) binding to nicotinic acid receptor in rat spleen membrane.


J Med Chem 46: 3945-51 (2003)


Article DOI: 10.1021/jm030888c
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50220842
PNG
(3-butyl-1H-pyrazole-5-carboxylic acid | 5-butyl-1H...)
Show SMILES CCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
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n/an/an/an/a 1.40E+3n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human cloned GPR109a receptor by forskolin-stimulated cAMP production test


Bioorg Med Chem Lett 17: 4914-9 (2007)


Article DOI: 10.1016/j.bmcl.2007.06.028
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50220842
PNG
(3-butyl-1H-pyrazole-5-carboxylic acid | 5-butyl-1H...)
Show SMILES CCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
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PC cid
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Article
PubMed
n/an/an/an/a 85n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
More data for this
Ligand-Target Pair
Hydroxycarboxylic acid receptor 2


(Homo sapiens (Human))
BDBM50220842
PNG
(3-butyl-1H-pyrazole-5-carboxylic acid | 5-butyl-1H...)
Show SMILES CCCCc1cc(n[nH]1)C(O)=O
Show InChI InChI=1S/C8H12N2O2/c1-2-3-4-6-5-7(8(11)12)10-9-6/h5H,2-4H2,1H3,(H,9,10)(H,11,12)
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
AffyNet 
Purchase

CHEMBL
PC cid
PC sid
UniChem

Patents

Article
PubMed
n/an/an/an/a 85n/an/an/an/a



Arena Pharmaceuticals

Curated by ChEMBL


Assay Description
Agonist activity at human GPR109a expressed in human adipocytes assessed as decrease in intracellular cAMP level by HTRF assay


Bioorg Med Chem Lett 17: 5620-3 (2007)

Checked by Author
Article DOI: 10.1016/j.bmcl.2007.07.101
More data for this
Ligand-Target Pair