Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM50206600 (3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 700 | n/a | n/a | n/a | n/a | n/a | n/a |
Molecular Cancer Research Center Curated by ChEMBL | Assay Description Inhibition of hypoxia induced HIF1alpha transcriptional activity in human AGS cells by reporter gene assay | Bioorg Med Chem Lett 17: 6305-10 (2007) Article DOI: 10.1016/j.bmcl.2007.09.005 BindingDB Entry DOI: 10.7270/Q2PR7VQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM50206600 (3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 2.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Molecular Cancer Research Center Curated by ChEMBL | Assay Description Inhibition of hypoxia induced HIF1alpha transcriptional activity in human Hep3B cells by reporter gene assay | Bioorg Med Chem Lett 17: 6305-10 (2007) Article DOI: 10.1016/j.bmcl.2007.09.005 BindingDB Entry DOI: 10.7270/Q2PR7VQT | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Hypoxia-inducible factor 1-alpha (Homo sapiens (Human)) | BDBM50206600 (3-[2-(4-adamantan-1-yl-phenoxy)-acetylamino]-benzo...) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | CHEMBL PC cid PC sid UniChem Patents Similars | Article PubMed | n/a | n/a | 5.03E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Dongguk University-Seoul Curated by ChEMBL | Assay Description Inhibition of HIF1alpha in human HCT116 cells under hypoxic condition after 16 hrs by dual luciferase reporter gene assay | J Med Chem 55: 10564-71 (2012) Article DOI: 10.1021/jm301419d BindingDB Entry DOI: 10.7270/Q2QR4Z8D | |||||||||||
More data for this Ligand-Target Pair |