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Found 1 hit Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor prolyl hydroxylase 1' and Ligand = 'BDBM50385810'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM50385810
PNG
(CHEMBL2043008)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1ccccc1)c1ccc(=O)[nH]n1
Show InChI InChI=1S/C30H28N6O3/c1-21-6-5-17-31-25(21)20-34-18-15-30(16-19-34)28(38)35(29(39)36(30)26-13-14-27(37)33-32-26)24-11-9-23(10-12-24)22-7-3-2-4-8-22/h2-14,17H,15-16,18-20H2,1H3,(H,33,37)
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PC cid
PC sid
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Article
PubMed
n/an/a 2.10n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PHD1


J Med Chem 55: 2945-59 (2012)


Article DOI: 10.1021/jm201542d
More data for this
Ligand-Target Pair