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Found 1 hit Enz. Inhib. hit(s) with Target = 'Hypoxia-inducible factor prolyl hydroxylase 1' and Ligand = 'BDBM50385829'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia-inducible factor prolyl hydroxylase 1


(Homo sapiens (Human))
BDBM50385829
PNG
(CHEMBL2041167)
Show SMILES Cc1cccnc1CN1CCC2(CC1)N(C(=O)N(C2=O)c1ccc(cc1)-c1cnc(=O)[nH]c1)c1cc(=O)[nH]cn1
Show InChI InChI=1S/C28H26N8O4/c1-18-3-2-10-29-22(18)16-34-11-8-28(9-12-34)25(38)35(27(40)36(28)23-13-24(37)33-17-32-23)21-6-4-19(5-7-21)20-14-30-26(39)31-15-20/h2-7,10,13-15,17H,8-9,11-12,16H2,1H3,(H,30,31,39)(H,32,33,37)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 2n/an/an/an/an/an/a



Merck Research Laboratories

Curated by ChEMBL


Assay Description
Inhibition of PHD1


J Med Chem 55: 2945-59 (2012)


Article DOI: 10.1021/jm201542d
More data for this
Ligand-Target Pair