Found 31 hits Enz. Inhib. hit(s) with Target = 'Indoleamine 2,3-dioxygenase 1' and Ligand = 'BDBM50241727' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
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| 6.60E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of British Columbia
Curated by ChEMBL
| Assay Description Inhibition of human indoleamine 2,3-dioxygenase expressed in Escherichia coli by spectrophotometric activity assay |
J Nat Prod 69: 1496-9 (2006)
Article DOI: 10.1021/np060111x BindingDB Entry DOI: 10.7270/Q27W6BZQ |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
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| 7.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur
Curated by ChEMBL
| Assay Description Competitive inhibition of histidine-tagged human recombinant IDO expressed in bacterial strain BL21 AI using L-Trptophan as substrate measured at 490... |
Eur J Med Chem 46: 3058-65 (2011)
Article DOI: 10.1016/j.ejmech.2011.02.049 BindingDB Entry DOI: 10.7270/Q2F19029 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| 1.90E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of IDO by cell-free assay |
J Med Chem 53: 1172-89 (2010)
Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| 3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of IDO1 (unknown origin) |
Eur J Med Chem 138: 199-211 (2017)
Article DOI: 10.1016/j.ejmech.2017.06.039 BindingDB Entry DOI: 10.7270/Q2C25012 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Competitive inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as apparent inhibition constant using varying conc... |
J Med Chem 62: 9161-9174 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01079 BindingDB Entry DOI: 10.7270/Q27W6GJ0 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| 3.40E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Competitive inhibition of human IDO1 in presence of tryptophan |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| 3.70E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur
Curated by ChEMBL
| Assay Description Inhibition of IDO |
Bioorg Med Chem 19: 1550-61 (2011)
Article DOI: 10.1016/j.bmc.2010.12.032 BindingDB Entry DOI: 10.7270/Q27M087F |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| 4.23E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant IDO1 using L-tryptophan as substrate |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| 5.32E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
The University of Tokushima
Curated by ChEMBL
| Assay Description Inhibition of indoleamine 2,3-dioxygenase (unknown origin) in aerobic condition |
Bioorg Med Chem 16: 8661-9 (2008)
Article DOI: 10.1016/j.bmc.2008.07.087 BindingDB Entry DOI: 10.7270/Q2W66KKP |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
Indian Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured aft... |
ACS Med Chem Lett 7: 1167-1172 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00359 BindingDB Entry DOI: 10.7270/Q2TF009K |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Macquarie University
Curated by ChEMBL
| Assay Description Inhibition of His-tagged recombinant human IDO1 expressed in Escherichia coli using tryptophan as substrate by spectrophotometric analysis |
Bioorg Med Chem 20: 1354-63 (2012)
Article DOI: 10.1016/j.bmc.2011.10.068 BindingDB Entry DOI: 10.7270/Q28P60ZT |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of human IDO1 expressed in HEK293 cells assessed as kynurenine release after 5 hrs by spectrophotometry |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of IDO1 in human HeLa cells |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00925 BindingDB Entry DOI: 10.7270/Q28D010N |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 1.84E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human IDO1 expressed in HEK293 cells assessed as reduction in kynurenine formation after 5 hrs by microplate reader analysi... |
J Med Chem 62: 9161-9174 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01079 BindingDB Entry DOI: 10.7270/Q27W6GJ0 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SIB Swiss Institute for Bioinformatics
Curated by ChEMBL
| Assay Description Inhibition of human IDO1 expressed in Escherichia coli BL21 Star assessed as kynurenine formation using L-Trp as substrate preincubated for 90 mins m... |
Bioorg Med Chem Lett 26: 4330-3 (2016)
Article DOI: 10.1016/j.bmcl.2016.07.031 BindingDB Entry DOI: 10.7270/Q2J38X2Q |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 3.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
SIB Swiss Institute for Bioinformatics
Curated by ChEMBL
| Assay Description Inhibition of human IDO1 expressed in Escherichia coli BL21 Star assessed as kynurenine formation using L-Trp as substrate preincubated for 90 mins m... |
Bioorg Med Chem Lett 26: 4330-3 (2016)
Article DOI: 10.1016/j.bmcl.2016.07.031 BindingDB Entry DOI: 10.7270/Q2J38X2Q |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Mus musculus) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | Reactome pathway KEGG
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| n/a | n/a | 4.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of mouse recombinant IDO expressed in mouse P815B cells assessed as blockade of tryptophan degradation by HPLC |
J Med Chem 53: 1172-89 (2010)
Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 4.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21(DE3) assessed as effect on kynurenine level using L-tryptophan as substrate i... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.0c00925 BindingDB Entry DOI: 10.7270/Q28D010N |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 7.73E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
China Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of IFNgamma-induced IDO1 in human HeLa cells using L-tryptophan as substrate after 24 hrs |
Eur J Med Chem 138: 199-211 (2017)
Article DOI: 10.1016/j.ejmech.2017.06.039 BindingDB Entry DOI: 10.7270/Q2C25012 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 9.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Institute for Cancer Research
Curated by ChEMBL
| Assay Description Inhibition of human recombinant IDO expressed in HEK293 cells assessed as blockade of tryptophan degradation by HPLC |
J Med Chem 53: 1172-89 (2010)
Article DOI: 10.1021/jm9014718 BindingDB Entry DOI: 10.7270/Q2BC40G9 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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| n/a | n/a | 9.85E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of purified recombinant human IDO1 using L-tryptophan substrate incubated fro 30 mins |
Bioorg Med Chem 27: 3135-3144 (2019)
Article DOI: 10.1016/j.bmc.2019.05.048 BindingDB Entry DOI: 10.7270/Q2JH3QH9 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur (UNamur)
Curated by ChEMBL
| Assay Description Inhibition of recombinant N-terminal His-tagged human IDO (Ala2 to Gly403) overexpressed in Escherichia coli BL21 AI using L-tryptophan as substrate ... |
Eur J Med Chem 82: 96-105 (2014)
Article DOI: 10.1016/j.ejmech.2014.05.044 BindingDB Entry DOI: 10.7270/Q28G8N8D |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur
Curated by ChEMBL
| Assay Description Inhibition of human IDO activity by spectrophotometry |
Bioorg Med Chem 19: 1550-61 (2011)
Article DOI: 10.1016/j.bmc.2010.12.032 BindingDB Entry DOI: 10.7270/Q27M087F |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.19E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Shenyang Pharmaceutical University
Curated by ChEMBL
| Assay Description Inhibition of IDO1 in interferon-gamma-induced human HeLa cells using L-tryptophan substrate incubated for 24 hrs |
Bioorg Med Chem 27: 3135-3144 (2019)
Article DOI: 10.1016/j.bmc.2019.05.048 BindingDB Entry DOI: 10.7270/Q2JH3QH9 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
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CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.39E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Namur
Curated by ChEMBL
| Assay Description Inhibition of human recombinant IDO1 using L-Trp as substrate assessed as kynurenine level after 30 mins |
Bioorg Med Chem Lett 23: 47-54 (2012)
Article DOI: 10.1016/j.bmcl.2012.11.036 BindingDB Entry DOI: 10.7270/Q2JM2C03 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | >2.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of human IDO1-mediated tryptophan degradation expressed in human tumor cells |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of IDO1 (unknown origin) using L-Trp as substrate |
Eur J Med Chem 160: 133-145 (2018)
Article DOI: 10.1016/j.ejmech.2018.10.017 BindingDB Entry DOI: 10.7270/Q2GB27GB |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.80E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Inhibition of recombinant human IDO1 expressed in Escherichia coli BL21 cells assessed as reduction in conversion of L-tryptophan to N-formyl kynuren... |
J Med Chem 62: 9161-9174 (2019)
Article DOI: 10.1021/acs.jmedchem.9b01079 BindingDB Entry DOI: 10.7270/Q27W6GJ0 |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 3.85E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Indian Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of N-terminus 6xHis-tagged human IDO1 expressed in Escherichia coli M15 using L-tryptophan as substrate preincubated for 1 hr measured aft... |
ACS Med Chem Lett 7: 1167-1172 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00359 BindingDB Entry DOI: 10.7270/Q2TF009K |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 4.99E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Fudan University
Curated by ChEMBL
| Assay Description Competitive inhibition of human recombinant IDO1 using L-tryptophan as substrate |
J Med Chem 56: 8321-31 (2013)
Article DOI: 10.1021/jm401195n BindingDB Entry DOI: 10.7270/Q2X34ZWS |
More data for this Ligand-Target Pair | |
Indoleamine 2,3-dioxygenase 1
(Homo sapiens (Human)) | BDBM50241727
((S)-2-amino-3-(1-methyl-1H-indol-3-yl)propanoic ac...)Show InChI InChI=1S/C12H14N2O2/c1-14-7-8(6-10(13)12(15)16)9-4-2-3-5-11(9)14/h2-5,7,10H,6,13H2,1H3,(H,15,16)/t10-/m0/s1 | PDB MMDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | n/a | n/a | 1.20E+5 | n/a | n/a | n/a | n/a |
Indian Institute of Technology
Curated by ChEMBL
| Assay Description Inhibition of IDO1 in IFNgamma-induced human MDA-MB-231 cells using tryptophan as substrate preincubated for 4 hrs followed by substrate addition for... |
ACS Med Chem Lett 7: 1167-1172 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00359 BindingDB Entry DOI: 10.7270/Q2TF009K |
More data for this Ligand-Target Pair | |