Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM278743'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM278743 (2-[(3R)- or (3S)-azepan- 3-ylamino]-N-[1- methyl-3...) Show SMILES OC(=O)C(F)(F)F.Cn1cc(NC(=O)c2ccc3ccc(N[C@H]4CCCCNC4)nn23)c(n1)C(F)(F)F |r| Show InChI InChI=1S/C19H22F3N7O.C2HF3O2/c1-28-11-14(17(27-28)19(20,21)22)25-18(30)15-7-5-13-6-8-16(26-29(13)15)24-12-4-2-3-9-23-10-12;3-2(4,5)1(6)7/h5-8,11-12,23H,2-4,9-10H2,1H3,(H,24,26)(H,25,30);(H,6,7)/t12-;/m0./s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	2	n/a	n/a	n/a	n/a	7.2	n/a
Merck Sharp & Dohme Corp. US Patent					Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...				US Patent US10040798 (2018) BindingDB Entry DOI: 10.7270/Q2F191Q7
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