Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Interleukin-1 receptor-associated kinase 4' and Ligand = 'BDBM50242696'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM50242696 (CHEMBL4083650 | US9932350, 2-5) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:6.9,wD:3.2,(31.71,-18.38,;30.38,-17.61,;30.38,-16.07,;29.05,-18.38,;27.71,-17.61,;26.37,-18.39,;26.38,-19.92,;27.72,-20.69,;29.05,-19.92,;25.06,-20.69,;25.06,-22.23,;26.4,-22.99,;26.41,-24.54,;25.07,-25.32,;23.74,-24.55,;22.41,-25.33,;21.07,-24.56,;21.07,-23.01,;22.4,-22.24,;23.74,-23.01,;19.74,-22.24,;18.41,-21.48,)| Show InChI InChI=1S/C17H21N5/c1-22(2)14-6-4-13(5-7-14)21-17-15-9-12(10-18)3-8-16(15)19-11-20-17/h3,8-9,11,13-14H,4-7H2,1-2H3,(H,19,20,21)/t13-,14-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of recombinant human full length GST tagged IRAK4 expressed in baculovirus infected Sf9 cells using RP7030 peptide as substrate after 30 m...				Bioorg Med Chem Lett 27: 2721-2726 (2017) Article DOI: 10.1016/j.bmcl.2017.04.050 BindingDB Entry DOI: 10.7270/Q2RR21NQ
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Homo sapiens (Human))	BDBM50242696 (CHEMBL4083650 | US9932350, 2-5) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:6.9,wD:3.2,(31.71,-18.38,;30.38,-17.61,;30.38,-16.07,;29.05,-18.38,;27.71,-17.61,;26.37,-18.39,;26.38,-19.92,;27.72,-20.69,;29.05,-19.92,;25.06,-20.69,;25.06,-22.23,;26.4,-22.99,;26.41,-24.54,;25.07,-25.32,;23.74,-24.55,;22.41,-25.33,;21.07,-24.56,;21.07,-23.01,;22.4,-22.24,;23.74,-23.01,;19.74,-22.24,;18.41,-21.48,)| Show InChI InChI=1S/C17H21N5/c1-22(2)14-6-4-13(5-7-14)21-17-15-9-12(10-18)3-8-16(15)19-11-20-17/h3,8-9,11,13-14H,4-7H2,1-2H3,(H,19,20,21)/t13-,14-	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	US Patent	n/a	n/a	7	n/a	n/a	n/a	n/a	n/a	n/a
Istanbul University					Assay Description The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...				Bioorg Med Chem 16: 9113-20 (2008) BindingDB Entry DOI: 10.7270/Q2NS0X7R
					More data for this Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4 (Rattus norvegicus)	BDBM50242696 (CHEMBL4083650 | US9932350, 2-5) Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N |r,wU:6.9,wD:3.2,(31.71,-18.38,;30.38,-17.61,;30.38,-16.07,;29.05,-18.38,;27.71,-17.61,;26.37,-18.39,;26.38,-19.92,;27.72,-20.69,;29.05,-19.92,;25.06,-20.69,;25.06,-22.23,;26.4,-22.99,;26.41,-24.54,;25.07,-25.32,;23.74,-24.55,;22.41,-25.33,;21.07,-24.56,;21.07,-23.01,;22.4,-22.24,;23.74,-23.01,;19.74,-22.24,;18.41,-21.48,)| Show InChI InChI=1S/C17H21N5/c1-22(2)14-6-4-13(5-7-14)21-17-15-9-12(10-18)3-8-16(15)19-11-20-17/h3,8-9,11,13-14H,4-7H2,1-2H3,(H,19,20,21)/t13-,14-	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of IRAK4 in Lewis rat whole blood assessed as reduction in R848-stimulated TNF alpha production after 4 hrs				Bioorg Med Chem Lett 27: 2721-2726 (2017) Article DOI: 10.1016/j.bmcl.2017.04.050 BindingDB Entry DOI: 10.7270/Q2RR21NQ
					More data for this Ligand-Target Pair