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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Interlukin-2-inducible tyrosine kinase (Itk)' and Ligand = 'BDBM213214'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interlukin-2-inducible tyrosine kinase (Itk)


(Homo sapiens (Human))
BDBM213214
PNG
(N2-(1-Acryloyl-4-piperidinyl)-6-(4-morpholinylmeth...)
Show SMILES C=CC(=O)N1CCC(CC1)Nc1nc(CN2CCOCC2)cc(Nc2nc3cccnc3s2)n1
Show InChI InChI=1S/C23H28N8O2S/c1-2-20(32)31-8-5-16(6-9-31)25-22-26-17(15-30-10-12-33-13-11-30)14-19(28-22)29-23-27-18-4-3-7-24-21(18)34-23/h2-4,7,14,16H,1,5-6,8-13,15H2,(H2,25,26,27,28,29)
PDB

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 320n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...


J Biol Chem 288: 28195-206 (2013)


Article DOI: 10.1074/jbc.M113.474114
BindingDB Entry DOI: 10.7270/Q2ZW1JSK
More data for this
Ligand-Target Pair