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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Lck' and Ligand = 'BDBM26157'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Mus musculus)
BDBM26157
PNG
(2,4-dianilino pyrimidine, 14 | 3-({4-[(5-amino-2-m...)
Show SMILES Cc1ccc(N)cc1Nc1ccnc(Nc2cccc(c2)C(N)=O)n1
Show InChI InChI=1S/C18H18N6O/c1-11-5-6-13(19)10-15(11)23-16-7-8-21-18(24-16)22-14-4-2-3-12(9-14)17(20)25/h2-10H,19H2,1H3,(H2,20,25)(H2,21,22,23,24)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 97n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair