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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Lck' and Ligand = 'BDBM26172'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lck


(Mus musculus)
BDBM26172
PNG
(2,4-dianilino pyrimidine, 29 | 3-({4-[(1-methyl-1H...)
Show SMILES Cn1cnc2cc(Nc3ccnc(Nc4cccc(c4)C(N)=O)n3)ccc12
Show InChI InChI=1S/C19H17N7O/c1-26-11-22-15-10-14(5-6-16(15)26)23-17-7-8-21-19(25-17)24-13-4-2-3-12(9-13)18(20)27/h2-11H,1H3,(H2,20,27)(H2,21,23,24,25)
PDB
MMDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 1.80E+3n/an/an/an/a7.422



GSK



Assay Description
Lck activity was assessed using a TR-FRET assay in a 384-well plate format. The degree of phosphorylation of Biotinylated substrate was measured usin...


Bioorg Med Chem Lett 17: 4363-8 (2007)


Article DOI: 10.1016/j.bmcl.2007.04.029
BindingDB Entry DOI: 10.7270/Q21R6NTD
More data for this
Ligand-Target Pair