new BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)' and Ligand = 'BDBM127916'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2)


(Homo sapiens (Human))
BDBM127916
PNG
(US8791130, 46)
Show SMILES CNc1nc(Nc2cc(C)c(cc2OC)-n2nnnc2COC)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N8O2/c1-9-5-11(23-16-22-7-10(17(18,19)20)15(21-2)24-16)13(30-4)6-12(9)28-14(8-29-3)25-26-27-28/h5-7H,8H2,1-4H3,(H2,21,22,23,24)
PDB

KEGG

UniProtKB/SwissProt

B.MOAD
antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
1n/an/an/an/an/an/an/an/a



Genentech, Inc.

US Patent


Assay Description
This assay was used to determine a compound's potency in inhibiting activity of LRRK2 by determining, Kiapp, IC50, or percent inhibition values. ...


US Patent US8791130 (2014)


BindingDB Entry DOI: 10.7270/Q2K9367R
More data for this
Ligand-Target Pair