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Found 1 hit Enz. Inhib. hit(s) with Target = 'Lysine-specific histone demethylase 1A' and Ligand = 'BDBM301077'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))		BDBM301077
PNG
(4-[2-(4-aminopiperidin-1-yl)-5-[2-(1- hydroxycyclo...)
Show SMILES NC1CCN(CC1)c1ncc(C#CC2(O)CCCC2)c(n1)-c1ccc(cc1)C#N
Show InChI InChI=1S/C23H25N5O/c24-15-17-3-5-18(6-4-17)21-19(7-12-23(29)10-1-2-11-23)16-26-22(27-21)28-13-8-20(25)9-14-28/h3-6,16,20,29H,1-2,8-11,13-14,25H2
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US Patent
n/an/a<10n/an/an/an/an/an/a



Celgene Quanticel Research, Inc.

US Patent


Assay Description
The enzymatic assay of LSD1 activity is based on Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) detection. The inhibitory properties ...

US Patent US10131664 (2018)


BindingDB Entry DOI: 10.7270/Q2JD4ZV1
More data for this
Ligand-Target Pair