Found 21 hits Enz. Inhib. hit(s) with Target = 'Lysosomal alpha-glucosidase' and Ligand = 'BDBM18351' Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| 59 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of human GAA using 4-methylumbelliferyl-alpha-D-glucopyranoside as substrate preincubated for 45 min followed by substrate addition and me... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c01673 BindingDB Entry DOI: 10.7270/Q23J3HVM |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article
| 150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Tested in vitro for the inhibition constant against human lysosomal alpha-glucosidase |
Bioorg Med Chem Lett 7: 355-360 (1997)
Article DOI: 10.1016/S0960-894X(97)00012-7 BindingDB Entry DOI: 10.7270/Q2F18ZQ1 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| | 3.40E+3 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Technische Universit£t Berlin
Curated by ChEMBL
| Assay Description Inhibitory activity against alpha-glucosidase of yeast |
Bioorg Med Chem Lett 9: 615-8 (1999)
BindingDB Entry DOI: 10.7270/Q2V40VQH |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of maltase in human Caco-2 cell model system after 2 hrs |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal brush border membrane maltase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal maltase assessed as D-glucose release after 30 mins by Glucose B-test |
J Nat Prod 65: 1875-81 (2002)
Article DOI: 10.1021/np020296h BindingDB Entry DOI: 10.7270/Q2NC60Z4 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Toyama
Curated by ChEMBL
| Assay Description Inhibition of rat intestinal maltase using moltose as substrate |
J Med Chem 55: 10347-62 (2012)
Article DOI: 10.1021/jm301304e BindingDB Entry DOI: 10.7270/Q2K35VTX |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of rat liver lysosome alpha-glucosidase assessed as D-glucose release after 30 mins by Glucose B-test |
J Nat Prod 65: 1875-81 (2002)
Article DOI: 10.1021/np020296h BindingDB Entry DOI: 10.7270/Q2NC60Z4 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| | n/a | n/a | 410 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| |
Citation and Details
|
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal alpha-glucosidase |
Bioorg Med Chem 16: 7330-6 (2008)
Article DOI: 10.1016/j.bmc.2008.06.026 BindingDB Entry DOI: 10.7270/Q27D2W2B |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of lysosomal alpha-glucosidase by HPLC |
J Med Chem 53: 689-98 (2010)
Article DOI: 10.1021/jm901281m BindingDB Entry DOI: 10.7270/Q2M908TC |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article PubMed
| n/a | n/a | 1.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Leiden University
Curated by ChEMBL
| Assay Description Inhibition of human lysosomal alpha glucosidase |
Bioorg Med Chem Lett 19: 6600-3 (2009)
Article DOI: 10.1016/j.bmcl.2009.10.022 BindingDB Entry DOI: 10.7270/Q2736QZB |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Bos taurus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver |
J Med Chem 37: 3701-6 (1994)
BindingDB Entry DOI: 10.7270/Q2ZC83H3 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Bos taurus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.10E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Inhibition of mammalian alpha-glucosidase (lysosomal) was determined in bovine liver |
J Med Chem 37: 3701-6 (1994)
BindingDB Entry DOI: 10.7270/Q2ZC83H3 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 2.50E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver |
J Med Chem 37: 3701-6 (1994)
BindingDB Entry DOI: 10.7270/Q2ZC83H3 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Homo sapiens (Human)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
NCI pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article
| n/a | n/a | 9.19E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity was determined against baker's yeast Alpha-Glucosidase |
Bioorg Med Chem Lett 4: 2643-2648 (1994)
Article DOI: 10.1016/S0960-894X(01)80688-0 BindingDB Entry DOI: 10.7270/Q21V5FFN |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Bos taurus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| Article
| n/a | n/a | >3.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
Curated by ChEMBL
| Assay Description Inhibitory activity was determined against bovine liver beta galactosidase |
Bioorg Med Chem Lett 4: 2643-2648 (1994)
Article DOI: 10.1016/S0960-894X(01)80688-0 BindingDB Entry DOI: 10.7270/Q21V5FFN |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 5.60E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Concentration that causes 50% inhibition of mammalian alpha-glucosidase (maltase) was determined in rat intestine |
J Med Chem 37: 3701-6 (1994)
BindingDB Entry DOI: 10.7270/Q2ZC83H3 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Rattus norvegicus) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| PubMed
| n/a | n/a | 1.00E+6 | n/a | n/a | n/a | n/a | n/a | n/a |
Hokuriku University
Curated by ChEMBL
| Assay Description Concentration that causes 50% inhibition of mammalian alpha-glucosidase (lysosomal) was determined in rat liver |
J Med Chem 37: 3701-6 (1994)
BindingDB Entry DOI: 10.7270/Q2ZC83H3 |
More data for this Ligand-Target Pair | |
Lysosomal alpha-glucosidase
(Mus musculus (Mouse)) | BDBM18351
((2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-tr...)Show InChI InChI=1S/C6H13NO4/c8-2-3-5(10)6(11)4(9)1-7-3/h3-11H,1-2H2/t3-,4+,5-,6-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet
| Purchase
CHEMBL MCE KEGG MMDB PC cid PC sid PDB UniChem
Patents
Similars
| US Patent
| n/a | n/a | n/a | n/a | 9.88E+4 | n/a | n/a | 4.0 | n/a |
Amicus Therapeutics, Inc.
US Patent
| Assay Description Cells were washed two times with 200 μL dPBS followed by the addition of 70 μL of substrate (2.11 mM 3 mM 4-MU-α-D-glu) in citrate-pho... |
US Patent US9181184 (2015)
BindingDB Entry DOI: 10.7270/Q2T43RWB |
More data for this Ligand-Target Pair | |