BindingDB PrimarySearch

Found 7 hits Enz. Inhib. hit(s) with Target = 'MAP kinase-activated protein kinase 2' and Ligand = 'BDBM50059889'
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	36.3	n/a	n/a	n/a	n/a	n/a	n/a
Centre Universitaire Curated by ChEMBL					Assay Description Inhibition of MAPKAPK2				Eur J Med Chem 45: 3389-93 (2010) Article DOI: 10.1016/j.ejmech.2010.04.026 BindingDB Entry DOI: 10.7270/Q2TH8MWC
Centre Universitaire Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	150	n/a	n/a	n/a	n/a	n/a	n/a
Griffith University Curated by ChEMBL					Assay Description Inhibition of GST-tagged MAPKAPK2 assessed as [33P] incorporation after 40 mins by scintillation proximity assay				J Nat Prod 72: 1699-701 (2009) Article DOI: 10.1021/np900246t BindingDB Entry DOI: 10.7270/Q2X0675D
Griffith University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
Teijin Pharma Ltd. Curated by ChEMBL					Assay Description Inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP after 30 mins by liquid scintillation counter				J Med Chem 55: 6700-15 (2012) Article DOI: 10.1021/jm300411k BindingDB Entry DOI: 10.7270/Q20K29PX
Teijin Pharma Ltd. Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	660	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Inhibition of human recombinant phospho-MK2 (36-400) by HTRF assay				Bioorg Med Chem Lett 20: 330-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.102 BindingDB Entry DOI: 10.7270/Q24M95GT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [8-3H]ATP from human recombinant phospho-MK2 (36-400) by scintillation proximity assay				Bioorg Med Chem Lett 20: 330-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.102 BindingDB Entry DOI: 10.7270/Q24M95GT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [8-3H]ATP from human recombinant MK2 (36-400) by scintillation proximity assay				Bioorg Med Chem Lett 20: 330-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.102 BindingDB Entry DOI: 10.7270/Q24M95GT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)
MAP kinase-activated protein kinase 2 (Homo sapiens (Human))	BDBM50059889 ((staurosporine)3-methoxy-2-methyl-4-methylamino-(2...) Show SMILES Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	Purchase CHEMBL KEGG PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	3.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
Abbott Laboratories Curated by ChEMBL					Assay Description Displacement of [8-3H]ATP from human recombinant MK2 (41-364) by scintillation proximity assay				Bioorg Med Chem Lett 20: 330-3 (2010) Article DOI: 10.1016/j.bmcl.2009.10.102 BindingDB Entry DOI: 10.7270/Q24M95GT
Abbott Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (docked)