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Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 (CSF-1)' and Ligand = 'BDBM97735'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97735
PNG
(US8481564, 12)
Show SMILES O=C(Nc1ccc(cc1C1=CCCCC1)C1CNC(NC1)=NC#N)c1nc(c[nH]1)C#N |t:10,(6.88,1.32,;5.55,.55,;4.22,1.32,;2.88,.55,;2.88,-.99,;1.55,-1.76,;.22,-.99,;.22,.55,;1.55,1.32,;1.55,2.86,;2.88,3.63,;2.88,5.17,;1.55,5.94,;.22,5.17,;.22,3.63,;-1.12,-1.76,;-1.12,-3.3,;-2.45,-4.07,;-3.78,-3.3,;-3.78,-1.76,;-2.45,-.99,;-5.12,-4.07,;-6.45,-3.3,;-7.79,-2.53,;6.32,-.78,;5.42,-2.03,;6.32,-3.27,;7.79,-2.8,;7.79,-1.26,;5.55,-4.61,;4.78,-5.94,)|
Show InChI InChI=1S/C22H22N8O/c23-9-17-12-25-20(29-17)21(31)30-19-7-6-15(8-18(19)14-4-2-1-3-5-14)16-10-26-22(27-11-16)28-13-24/h4,6-8,12,16H,1-3,5,10-11H2,(H,25,29)(H,30,31)(H2,26,27,28)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 3n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)

More data for this
Ligand-Target Pair