BindingDB logo
myBDB logout
Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 (CSF-1)' and Ligand = 'BDBM97739'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Macrophage colony-stimulating factor 1 (CSF-1)


(Mus musculus (Mouse))
BDBM97739
PNG
(US8481564, 54)
Show SMILES CN1CC(CN(C)C1=NC#N)c1ccc(NC(=O)c2nc(c[nH]2)C#N)c(c1)C1=CCC(C)(C)CC1 |t:30,(-8.73,-1.92,;-7.39,-2.69,;-6.06,-1.93,;-4.73,-2.69,;-4.73,-4.23,;-6.06,-5,;-6.06,-6.54,;-7.39,-4.23,;-8.73,-5,;-8.73,-6.54,;-8.73,-8.08,;-3.39,-1.93,;-2.06,-2.69,;-.72,-1.93,;-.72,-.38,;.61,.38,;1.94,-.38,;1.94,-1.93,;3.28,.38,;3.28,1.93,;4.74,2.4,;5.65,1.15,;4.74,-.09,;5.51,3.73,;6.28,5.07,;-2.06,.38,;-3.39,-.38,;-2.06,1.93,;-.72,2.69,;-.72,4.23,;-2.06,5,;-3.15,6.09,;-.72,5.77,;-3.39,4.23,;-3.39,2.69,)|
Show InChI InChI=1S/C26H33N7O.C2HF3O2/c1-26(2)10-8-17(9-11-26)21-12-18(19-15-32(4)25(28-3)33(5)16-19)6-7-22(21)31-24(34)23-29-14-20(13-27)30-23;3-2(4,5)1(6)7/h6-8,12,14,19H,9-11,15-16H2,1-5H3,(H,29,30)(H,31,34);(H,6,7)/b28-25-;
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.420n/an/an/an/a7.5n/a



Janssen Pharmaceutica, N.V.

US Patent


Assay Description
A fluorescence polarization competition immunoassay was used to measure compound inhibition of CSF-1R phosphorylation of tyrosine on a synthetic CSF-...


US Patent US8481564 (2013)

More data for this
Ligand-Target Pair