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Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor' and Ligand = 'BDBM50255879'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255879
PNG
(CHEMBL4071474)
Show SMILES CN1CCN(CC1)c1ccc(Nc2ncc3CN(C(=O)N([C@H]4CCN(C4)C(=O)C=C)c3n2)c2ccccc2Cl)cc1C |r|
Show InChI InChI=1S/C31H35ClN8O2/c1-4-28(41)38-12-11-24(20-38)40-29-22(19-39(31(40)42)27-8-6-5-7-25(27)32)18-33-30(35-29)34-23-9-10-26(21(2)17-23)37-15-13-36(3)14-16-37/h4-10,17-18,24H,1,11-16,19-20H2,2-3H3,(H,33,34,35)/t24-/m0/s1
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Article
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n/an/a 30n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair