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Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor' and Ligand = 'BDBM50255902'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255902
PNG
(CHEMBL4066141)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCN(CC4)C4COC4)c(C)c3)nc12)c1cc(OC)ccc1Cl |r|
Show InChI InChI=1S/C34H41ClN8O4/c1-4-31(44)41-10-9-25(19-41)43-32-23(18-42(34(43)45)30-16-27(46-3)6-7-28(30)35)17-36-33(38-32)37-24-5-8-29(22(2)15-24)40-13-11-39(12-14-40)26-20-47-21-26/h5-8,15-17,25-26H,4,9-14,18-21H2,1-3H3,(H,36,37,38)/t25-/m0/s1
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Article
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n/an/a 3n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair