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Found 1 hit Enz. Inhib. hit(s) with Target = 'Macrophage colony-stimulating factor 1 receptor' and Ligand = 'BDBM50255946'   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Macrophage colony-stimulating factor 1 receptor


(Homo sapiens (Human))		BDBM50255946
PNG
(CHEMBL4083224)
Show SMILES CCC(=O)N1CC[C@@H](C1)N1C(=O)N(Cc2cnc(Nc3ccc(N4CCCN(C)CC4)c(C)c3)nc12)c1cc(OC)ccc1F |r|
Show InChI InChI=1S/C33H41FN8O3/c1-5-30(43)40-14-11-25(21-40)42-31-23(20-41(33(42)44)29-18-26(45-4)8-9-27(29)34)19-35-32(37-31)36-24-7-10-28(22(2)17-24)39-13-6-12-38(3)15-16-39/h7-10,17-19,25H,5-6,11-16,20-21H2,1-4H3,(H,35,36,37)/t25-/m0/s1
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Article
PubMed
n/an/a 4.90n/an/an/an/an/an/a



State Key Laboratory of Respiratory Diseases , Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , 190 Kaiyuan Avenue , Guangzhou 510530 , China.

Curated by ChEMBL


Assay Description
Inhibition of recombinant human His-tagged CSF1R cytoplasmic domain (538 to 910 residues) expressed in baculovirus using tyr4 peptide as substrate af...

J Med Chem 61: 2353-2371 (2018)


Article DOI: 10.1021/acs.jmedchem.7b01612
BindingDB Entry DOI: 10.7270/Q2NC63NB
More data for this
Ligand-Target Pair