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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Mast/stem cell growth factor receptor Kit' and Ligand = 'BDBM193923'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM193923
PNG
(US9199981, F13 | US9199981, F92)
Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC(F)(F)C1
Show InChI InChI=1S/C21H17F2N5O2/c1-12-5-6-13(18-26-20(30-27-18)14-9-21(22,23)10-14)8-15(12)25-19(29)16-11-24-17-4-2-3-7-28(16)17/h2-8,11,14H,9-10H2,1H3,(H,25,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 7n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...


US Patent US9199981 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TKJ
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))
BDBM193923
PNG
(US9199981, F13 | US9199981, F92)
Show SMILES Cc1ccc(cc1NC(=O)c1cnc2ccccn12)-c1noc(n1)C1CC(F)(F)C1
Show InChI InChI=1S/C21H17F2N5O2/c1-12-5-6-13(18-26-20(30-27-18)14-9-21(22,23)10-14)8-15(12)25-19(29)16-11-24-17-4-2-3-7-28(16)17/h2-8,11,14H,9-10H2,1H3,(H,25,29)
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 35n/an/an/an/an/an/a



NOVARTIS AG

US Patent


Assay Description
The compounds was tested for inhibition of SCF dependent proliferation using human Mo7e cells which endogenously express c-kit in a 384 well format. ...


US Patent US9199981 (2015)


BindingDB Entry DOI: 10.7270/Q2M32TKJ
More data for this
Ligand-Target Pair