Compile Data Set for Download or QSAR

Found 3 hits Enz. Inhib. hit(s) with Target = 'Maternal embryonic leucine zipper kinase' and Ligand = 'BDBM50248947'   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM50248947 (CHEMBL4075402 | US10981896, Compound 18) Show SMILES CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3ccc(cc23)C(C)=O)c2ccccc2)cc1 Show InChI InChI=1S/C31H33N5O3/c1-21(37)23-9-14-27-26(19-23)29(31(39)33-27)30(22-7-5-4-6-8-22)32-24-10-12-25(13-11-24)35(3)28(38)20-36-17-15-34(2)16-18-36/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,39)/b30-29-	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	46	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin Curated by ChEMBL					Assay Description Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...				Bioorg Med Chem 25: 2609-2616 (2017) Article DOI: 10.1016/j.bmc.2017.03.018 BindingDB Entry DOI: 10.7270/Q2833VFF
					More data for this Ligand-Target Pair
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM50248947 (CHEMBL4075402 | US10981896, Compound 18) Show SMILES CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3ccc(cc23)C(C)=O)c2ccccc2)cc1 Show InChI InChI=1S/C31H33N5O3/c1-21(37)23-9-14-27-26(19-23)29(31(39)33-27)30(22-7-5-4-6-8-22)32-24-10-12-25(13-11-24)35(3)28(38)20-36-17-15-34(2)16-18-36/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,39)/b30-29-	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	354	n/a	n/a	n/a	n/a	n/a	n/a
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM US Patent					Assay Description The top 10 hits from the 1 μM screening and derivatives of MELK-In-1 were subjected to the same assay conditions with varied inhibitor concentra...				US Patent US10981896 (2021) BindingDB Entry DOI: 10.7270/Q24X5BWV
					More data for this Ligand-Target Pair
Maternal embryonic leucine zipper kinase (Homo sapiens (Human))	BDBM50248947 (CHEMBL4075402 | US10981896, Compound 18) Show SMILES CN(C(=O)CN1CCN(C)CC1)c1ccc(N\C(=C2/C(=O)Nc3ccc(cc23)C(C)=O)c2ccccc2)cc1 Show InChI InChI=1S/C31H33N5O3/c1-21(37)23-9-14-27-26(19-23)29(31(39)33-27)30(22-7-5-4-6-8-22)32-24-10-12-25(13-11-24)35(3)28(38)20-36-17-15-34(2)16-18-36/h4-14,19,32H,15-18,20H2,1-3H3,(H,33,39)/b30-29-	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	354	n/a	n/a	n/a	n/a	n/a	n/a
The University of Texas at Austin Curated by ChEMBL					Assay Description Inhibition of His6-tagged MELK catalytic domain (1 to 340 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) cells using Bcl-GL as s...				Bioorg Med Chem 25: 2609-2616 (2017) Article DOI: 10.1016/j.bmc.2017.03.018 BindingDB Entry DOI: 10.7270/Q2833VFF
					More data for this Ligand-Target Pair