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Compile Data Set for Download or QSAR

Found 2 hits Enz. Inhib. hit(s) with Target = 'Melanin-concentrating hormone receptor' and Ligand = 'BDBM50207684'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50207684
PNG
(CHEMBL246050 | N-(1-(4-((2-(piperidin-1-yl)ethyl)c...)
Show SMILES Fc1ccc2c(c1)oc(cc2=O)C(=O)NC1CCN(Cc2ccc(cc2)C(=O)NCCN2CCCCC2)CC1
Show InChI InChI=1S/C30H35FN4O4/c31-23-8-9-25-26(36)19-28(39-27(25)18-23)30(38)33-24-10-15-35(16-11-24)20-21-4-6-22(7-5-21)29(37)32-12-17-34-13-2-1-3-14-34/h4-9,18-19,24H,1-3,10-17,20H2,(H,32,37)(H,33,38)
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CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 17n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Displacement of [125I]MCH from MCHR1 expressed in IMR32 cells


Bioorg Med Chem Lett 17: 2365-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.068
BindingDB Entry DOI: 10.7270/Q2N29WNW
More data for this
Ligand-Target Pair
Melanin-concentrating hormone receptor


(Homo sapiens (Human))
BDBM50207684
PNG
(CHEMBL246050 | N-(1-(4-((2-(piperidin-1-yl)ethyl)c...)
Show SMILES Fc1ccc2c(c1)oc(cc2=O)C(=O)NC1CCN(Cc2ccc(cc2)C(=O)NCCN2CCCCC2)CC1
Show InChI InChI=1S/C30H35FN4O4/c31-23-8-9-25-26(36)19-28(39-27(25)18-23)30(38)33-24-10-15-35(16-11-24)20-21-4-6-22(7-5-21)29(37)32-12-17-34-13-2-1-3-14-34/h4-9,18-19,24H,1-3,10-17,20H2,(H,32,37)(H,33,38)
Reactome pathway
KEGG

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 519n/an/an/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Antagonist activity at MCHR1 assessed as inhibition of MCH-mediated calcium release in IMR32 cells


Bioorg Med Chem Lett 17: 2365-71 (2007)


Article DOI: 10.1016/j.bmcl.2006.11.068
BindingDB Entry DOI: 10.7270/Q2N29WNW
More data for this
Ligand-Target Pair