Found 2 hits Enz. Inhib. hit(s) with Target = 'Melanocortin receptor 4' and Ligand = 'BDBM50184356' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50184356
(CHEMBL425591 | c[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH...)Show SMILES CCCC[C@@H]1NC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |wU:39.41,10.69,wD:14.14,54.58,28.30,4.3,(-1.57,-31.51,;-1.57,-33.05,;-.48,-33.77,;-.49,-35.29,;.74,-35.99,;2.44,-35.37,;2.43,-33.83,;1.1,-33.07,;3.65,-33.05,;4.17,-31.77,;5.69,-31.56,;6.46,-32.89,;7.21,-34.22,;8.7,-33.81,;7.62,-35.71,;9.15,-35.71,;9.92,-37.05,;9.92,-38.59,;11.38,-39.07,;12.28,-37.83,;13.81,-37.68,;14.45,-36.28,;13.54,-35.02,;12.02,-35.18,;11.39,-36.57,;6.68,-36.92,;7.26,-38.35,;8.8,-38.34,;6.86,-39.83,;7.95,-40.92,;9.44,-40.52,;10.52,-41.6,;12.01,-41.21,;13.1,-42.3,;14.59,-41.9,;12.7,-43.79,;5.52,-40.59,;4.2,-39.81,;4.2,-38.27,;2.86,-40.58,;2.85,-42.12,;4.19,-42.89,;5.51,-42.12,;6.84,-42.88,;6.84,-44.43,;8.17,-45.2,;8.17,-46.74,;6.83,-47.51,;5.5,-46.74,;5.5,-45.2,;4.18,-44.43,;1.52,-39.8,;.18,-40.57,;.17,-42.11,;-1.15,-39.79,;-2.48,-40.56,;-3.81,-39.79,;-3.98,-38.25,;-5.49,-37.93,;-6.27,-39.26,;-5.23,-40.41,;-1.16,-38.25,;.39,-37.51,;1.62,-38.26,;6.47,-30.22,;5.69,-28.89,;8.01,-30.23,)| Show InChI InChI=1S/C47H59N13O7/c1-2-3-12-35-42(63)60-39(23-31-25-51-26-54-31)46(67)58-37(21-27-15-16-28-9-4-5-10-29(28)20-27)44(65)57-36(14-8-19-52-47(49)50)43(64)59-38(22-30-24-53-33-13-7-6-11-32(30)33)45(66)56-34(41(48)62)17-18-40(61)55-35/h4-7,9-11,13,15-16,20,24-26,34-39,53H,2-3,8,12,14,17-19,21-23H2,1H3,(H2,48,62)(H,51,54)(H,55,61)(H,56,66)(H,57,65)(H,58,67)(H,59,64)(H,60,63)(H4,49,50,52)/t34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet 
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Inhibitory activity against hMC4R transfected in HEK293 cells |
J Med Chem 49: 1946-52 (2006)
Article DOI: 10.1021/jm0510326
BindingDB Entry DOI: 10.7270/Q2C24W1F |
More data for this
Ligand-Target Pair | |
Melanocortin receptor 4
(Homo sapiens (Human)) | BDBM50184356
(CHEMBL425591 | c[Nle-His-D-Nal(2')-Arg-Trp-Glu]-NH...)Show SMILES CCCC[C@@H]1NC(=O)CC[C@H](NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O)C(N)=O |wU:39.41,10.69,wD:14.14,54.58,28.30,4.3,(-1.57,-31.51,;-1.57,-33.05,;-.48,-33.77,;-.49,-35.29,;.74,-35.99,;2.44,-35.37,;2.43,-33.83,;1.1,-33.07,;3.65,-33.05,;4.17,-31.77,;5.69,-31.56,;6.46,-32.89,;7.21,-34.22,;8.7,-33.81,;7.62,-35.71,;9.15,-35.71,;9.92,-37.05,;9.92,-38.59,;11.38,-39.07,;12.28,-37.83,;13.81,-37.68,;14.45,-36.28,;13.54,-35.02,;12.02,-35.18,;11.39,-36.57,;6.68,-36.92,;7.26,-38.35,;8.8,-38.34,;6.86,-39.83,;7.95,-40.92,;9.44,-40.52,;10.52,-41.6,;12.01,-41.21,;13.1,-42.3,;14.59,-41.9,;12.7,-43.79,;5.52,-40.59,;4.2,-39.81,;4.2,-38.27,;2.86,-40.58,;2.85,-42.12,;4.19,-42.89,;5.51,-42.12,;6.84,-42.88,;6.84,-44.43,;8.17,-45.2,;8.17,-46.74,;6.83,-47.51,;5.5,-46.74,;5.5,-45.2,;4.18,-44.43,;1.52,-39.8,;.18,-40.57,;.17,-42.11,;-1.15,-39.79,;-2.48,-40.56,;-3.81,-39.79,;-3.98,-38.25,;-5.49,-37.93,;-6.27,-39.26,;-5.23,-40.41,;-1.16,-38.25,;.39,-37.51,;1.62,-38.26,;6.47,-30.22,;5.69,-28.89,;8.01,-30.23,)| Show InChI InChI=1S/C47H59N13O7/c1-2-3-12-35-42(63)60-39(23-31-25-51-26-54-31)46(67)58-37(21-27-15-16-28-9-4-5-10-29(28)20-27)44(65)57-36(14-8-19-52-47(49)50)43(64)59-38(22-30-24-53-33-13-7-6-11-32(30)33)45(66)56-34(41(48)62)17-18-40(61)55-35/h4-7,9-11,13,15-16,20,24-26,34-39,53H,2-3,8,12,14,17-19,21-23H2,1H3,(H2,48,62)(H,51,54)(H,55,61)(H,56,66)(H,57,65)(H,58,67)(H,59,64)(H,60,63)(H4,49,50,52)/t34-,35-,36-,37+,38-,39-/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
University of Arizona
Curated by ChEMBL
| Assay Description
Activity against hMC4R transfected in HEK293 cells by intracellular cAMP accumulation |
J Med Chem 49: 1946-52 (2006)
Article DOI: 10.1021/jm0510326
BindingDB Entry DOI: 10.7270/Q2C24W1F |
More data for this
Ligand-Target Pair | |
Search and Browse
